Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide
The present study was aimed to investigate the role of alpha lipoic acid (ALA) on reproductive hormonal profile in adult male Wister rats treated with hydrogen Peroxide. Forty adult male rats were divided randomly into four equal groups (10 rats /group) and were handled daily as follows for 56 days:...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, University of Kufa
2019-06-01
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| Series: | Kufa Journal for Veterinary Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/3326 |
| _version_ | 1797364096183566336 |
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| author | Mohammed Salih Alwan Baraa Najim Al-Okialy |
| author_facet | Mohammed Salih Alwan Baraa Najim Al-Okialy |
| author_sort | Mohammed Salih Alwan |
| collection | DOAJ |
| description | The present study was aimed to investigate the role of alpha lipoic acid (ALA) on reproductive hormonal profile in adult male Wister rats treated with hydrogen Peroxide. Forty adult male rats were divided randomly into four equal groups (10 rats /group) and were handled daily as follows for 56 days: Control group (C) were intubated distilled water and received tap water ; group T1 were intubated 60mg/kg B.W of ALA and received tap water; group T2 administered hydrogen peroxide H2O2 in tap water at concentration of 0.05%, while group T3 were intubated 60mg/kg B.W of ALA and received ordinary tap water containing 0.05% H2O2. Blood samples were collected at 0, 28 and 56 days of the experimental periods for measurement of serum follicular stimulation hormone (FSH), lutelizing hormone (LH) and testosterone (T) concentrations. The results revealed that group T2 showed a significant decrease in FSH and testosterone concentrations. While there were significant increase in previous parameters in T3 group compared to T2 group. Whereas, rats in group T3 shows significant improvement in above serum hormonal profile by repairing role of alpha lipoic acid against hydrogen peroxide in (group T2). In conclusion, alpha lipoic acid mitigated the deleterious effect of that-induced H2O2 induced pituitary-testicular dysfunction through antioxidant mechanism by free radical scavenging properties |
| first_indexed | 2024-03-08T16:30:26Z |
| format | Article |
| id | doaj.art-908f6e05853d453e97a7a9754f483034 |
| institution | Directory Open Access Journal |
| issn | 2077-9798 2959-8478 |
| language | English |
| last_indexed | 2024-03-08T16:30:26Z |
| publishDate | 2019-06-01 |
| publisher | Faculty of Veterinary Medicine, University of Kufa |
| record_format | Article |
| series | Kufa Journal for Veterinary Medical Sciences |
| spelling | doaj.art-908f6e05853d453e97a7a9754f4830342024-01-06T10:11:46ZengFaculty of Veterinary Medicine, University of KufaKufa Journal for Veterinary Medical Sciences2077-97982959-84782019-06-0110110.36326/kjvs/2019/v10i13326Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen PeroxideMohammed Salih Alwan0Baraa Najim Al-Okialy1Department of Physiology and Pharmacology, College of Veterinary Medicine/ University of Wasit, Iraq.Department of Physiology and Pharmacology, College of Veterinary Medicine/ University of Baghdad, Iraq.The present study was aimed to investigate the role of alpha lipoic acid (ALA) on reproductive hormonal profile in adult male Wister rats treated with hydrogen Peroxide. Forty adult male rats were divided randomly into four equal groups (10 rats /group) and were handled daily as follows for 56 days: Control group (C) were intubated distilled water and received tap water ; group T1 were intubated 60mg/kg B.W of ALA and received tap water; group T2 administered hydrogen peroxide H2O2 in tap water at concentration of 0.05%, while group T3 were intubated 60mg/kg B.W of ALA and received ordinary tap water containing 0.05% H2O2. Blood samples were collected at 0, 28 and 56 days of the experimental periods for measurement of serum follicular stimulation hormone (FSH), lutelizing hormone (LH) and testosterone (T) concentrations. The results revealed that group T2 showed a significant decrease in FSH and testosterone concentrations. While there were significant increase in previous parameters in T3 group compared to T2 group. Whereas, rats in group T3 shows significant improvement in above serum hormonal profile by repairing role of alpha lipoic acid against hydrogen peroxide in (group T2). In conclusion, alpha lipoic acid mitigated the deleterious effect of that-induced H2O2 induced pituitary-testicular dysfunction through antioxidant mechanism by free radical scavenging propertieshttps://journal.uokufa.edu.iq/index.php/kjvs/article/view/3326Alpha lipoic acidhydrogen peroxide LHFSH and testosterone |
| spellingShingle | Mohammed Salih Alwan Baraa Najim Al-Okialy Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide Kufa Journal for Veterinary Medical Sciences Alpha lipoic acid hydrogen peroxide LH FSH and testosterone |
| title | Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide |
| title_full | Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide |
| title_fullStr | Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide |
| title_full_unstemmed | Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide |
| title_short | Effect of alpha Lipoic Acid on Some Reproductive Hormones in Adult Male Wister Rats Exposed to Hydrogen Peroxide |
| title_sort | effect of alpha lipoic acid on some reproductive hormones in adult male wister rats exposed to hydrogen peroxide |
| topic | Alpha lipoic acid hydrogen peroxide LH FSH and testosterone |
| url | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/3326 |
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