Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients
Background/purpose: Our previous study found that 19.8%, 16.2%, 4.8%, 2.3%, 19.2%, and 12.3% of 884 burning mouth syndrome (BMS) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity, respectively....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S199179022100283X |
| _version_ | 1798022723696328704 |
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| author | Yu-Hsueh Wu Ying-Tai Jin Yang-Che Wu Julia Yu-Fong Chang Chun-Pin Chiang Andy Sun |
| author_facet | Yu-Hsueh Wu Ying-Tai Jin Yang-Che Wu Julia Yu-Fong Chang Chun-Pin Chiang Andy Sun |
| author_sort | Yu-Hsueh Wu |
| collection | DOAJ |
| description | Background/purpose: Our previous study found that 19.8%, 16.2%, 4.8%, 2.3%, 19.2%, and 12.3% of 884 burning mouth syndrome (BMS) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity, respectively. This study mainly evaluated the anemia, hematinic deficiencies, and hyperhomocysteinemia in 212 male and 672 female BMS patients. Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 212 male and 672 female BMS patients were measured and compared with the corresponding levels in 106 male and 336 female healthy control subjects, respectively. Results: We found that 212 male BMS patients had significantly lower mean blood Hb, serum iron, vitamin B12, and folic acid levels and significantly higher mean serum homocysteine levels than 106 male healthy control subjects. Moreover, 672 female BMS patients had significantly lower mean blood Hb and serum iron levels and significantly higher mean serum homocysteine level than 336 female healthy control subjects. In addition, 212 male BMS patients had significantly higher mean blood Hb and serum homocysteine levels, significantly lower mean serum vitamin B12 and folic acid levels, and significantly higher frequencies of folic acid deficiency and hyperhomocysteinemis than 672 female BMS patients. Conclusion: The male BMS patients do have significantly higher mean blood Hb and serum homocysteine levels, significantly lower mean serum vitamin B12 and folic acid levels, and significantly higher frequencies of folic acid deficiency and hyperhomocysteinemis than the female BMS patients. |
| first_indexed | 2024-04-11T17:34:39Z |
| format | Article |
| id | doaj.art-908f7f0aa7794edf95f4210fdf296e19 |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-04-11T17:34:39Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-908f7f0aa7794edf95f4210fdf296e192022-12-22T04:11:39ZengElsevierJournal of Dental Sciences1991-79022022-04-01172935941Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patientsYu-Hsueh Wu0Ying-Tai Jin1Yang-Che Wu2Julia Yu-Fong Chang3Chun-Pin Chiang4Andy Sun5Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Oral Medicine, School of Dentistry, National Cheng Kung University, Tainan, TaiwanDepartment of Pathology, Taiwan Adventist Hospital, Taipei, Taiwan; Department of Pathology, National Cheng Kung University Hospital, Tainan, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Corresponding author. Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan. Fax: +886 2 2389 3853Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10048, Taiwan. Fax: +886 2 2389 3853Background/purpose: Our previous study found that 19.8%, 16.2%, 4.8%, 2.3%, 19.2%, and 12.3% of 884 burning mouth syndrome (BMS) patients have anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity, respectively. This study mainly evaluated the anemia, hematinic deficiencies, and hyperhomocysteinemia in 212 male and 672 female BMS patients. Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 212 male and 672 female BMS patients were measured and compared with the corresponding levels in 106 male and 336 female healthy control subjects, respectively. Results: We found that 212 male BMS patients had significantly lower mean blood Hb, serum iron, vitamin B12, and folic acid levels and significantly higher mean serum homocysteine levels than 106 male healthy control subjects. Moreover, 672 female BMS patients had significantly lower mean blood Hb and serum iron levels and significantly higher mean serum homocysteine level than 336 female healthy control subjects. In addition, 212 male BMS patients had significantly higher mean blood Hb and serum homocysteine levels, significantly lower mean serum vitamin B12 and folic acid levels, and significantly higher frequencies of folic acid deficiency and hyperhomocysteinemis than 672 female BMS patients. Conclusion: The male BMS patients do have significantly higher mean blood Hb and serum homocysteine levels, significantly lower mean serum vitamin B12 and folic acid levels, and significantly higher frequencies of folic acid deficiency and hyperhomocysteinemis than the female BMS patients.http://www.sciencedirect.com/science/article/pii/S199179022100283XBurning mouth syndromeHemoglobinIronVitamin B12Folic acidHomocysteine |
| spellingShingle | Yu-Hsueh Wu Ying-Tai Jin Yang-Che Wu Julia Yu-Fong Chang Chun-Pin Chiang Andy Sun Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients Journal of Dental Sciences Burning mouth syndrome Hemoglobin Iron Vitamin B12 Folic acid Homocysteine |
| title | Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients |
| title_full | Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients |
| title_fullStr | Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients |
| title_full_unstemmed | Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients |
| title_short | Anemia, hematinic deficiencies, and hyperhomocysteinemia in male and female burning mouth syndrome patients |
| title_sort | anemia hematinic deficiencies and hyperhomocysteinemia in male and female burning mouth syndrome patients |
| topic | Burning mouth syndrome Hemoglobin Iron Vitamin B12 Folic acid Homocysteine |
| url | http://www.sciencedirect.com/science/article/pii/S199179022100283X |
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