Promising Antibiofilm Activity of Peptidomimetics
Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biof...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.02157/full |
| _version_ | 1819100680400404480 |
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| author | Rafael Gomes Von Borowski Rafael Gomes Von Borowski Simone Cristina Baggio Gnoatto Alexandre José Macedo Reynald Gillet |
| author_facet | Rafael Gomes Von Borowski Rafael Gomes Von Borowski Simone Cristina Baggio Gnoatto Alexandre José Macedo Reynald Gillet |
| author_sort | Rafael Gomes Von Borowski |
| collection | DOAJ |
| description | Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biofilms. Antimicrobial peptidomimetics have been proposed as promising potential anti-biofilm agents. Indeed, these structurally enhanced molecules can mimic the action of peptides but are not susceptible to proteolysis or immunogenicity, the characteristic limitations of natural peptides. Here, we provide insights into antibiofilm peptidomimetic strategies and molecular targets, and discuss the design of two major peptidomimetics classes: AApeptides (N-acylated-N-aminoethyl-substituted peptides) and peptoids (N-substituted glycine units). In particular, we present details of their structural diversity and discuss the possible improvements that can be implemented in order to develop antibiofilm drug alternatives. |
| first_indexed | 2024-12-22T01:06:37Z |
| format | Article |
| id | doaj.art-90930715f47347ae8b066acf2fd3eb50 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T01:06:37Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-90930715f47347ae8b066acf2fd3eb502022-12-21T18:44:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-09-01910.3389/fmicb.2018.02157406207Promising Antibiofilm Activity of PeptidomimeticsRafael Gomes Von Borowski0Rafael Gomes Von Borowski1Simone Cristina Baggio Gnoatto2Alexandre José Macedo3Reynald Gillet4Univ Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR), UMR 6290, Rennes, FrancePrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Biotechnology Center, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Biotechnology Center, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Biotechnology Center, Universidade Federal do Rio Grande do Sul, Porto Alegre, BrazilUniv Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR), UMR 6290, Rennes, FrancePathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biofilms. Antimicrobial peptidomimetics have been proposed as promising potential anti-biofilm agents. Indeed, these structurally enhanced molecules can mimic the action of peptides but are not susceptible to proteolysis or immunogenicity, the characteristic limitations of natural peptides. Here, we provide insights into antibiofilm peptidomimetic strategies and molecular targets, and discuss the design of two major peptidomimetics classes: AApeptides (N-acylated-N-aminoethyl-substituted peptides) and peptoids (N-substituted glycine units). In particular, we present details of their structural diversity and discuss the possible improvements that can be implemented in order to develop antibiofilm drug alternatives.https://www.frontiersin.org/article/10.3389/fmicb.2018.02157/fullantibiotic resistancebiofilmpeptidespeptidomimeticsAApeptidespeptoids |
| spellingShingle | Rafael Gomes Von Borowski Rafael Gomes Von Borowski Simone Cristina Baggio Gnoatto Alexandre José Macedo Reynald Gillet Promising Antibiofilm Activity of Peptidomimetics Frontiers in Microbiology antibiotic resistance biofilm peptides peptidomimetics AApeptides peptoids |
| title | Promising Antibiofilm Activity of Peptidomimetics |
| title_full | Promising Antibiofilm Activity of Peptidomimetics |
| title_fullStr | Promising Antibiofilm Activity of Peptidomimetics |
| title_full_unstemmed | Promising Antibiofilm Activity of Peptidomimetics |
| title_short | Promising Antibiofilm Activity of Peptidomimetics |
| title_sort | promising antibiofilm activity of peptidomimetics |
| topic | antibiotic resistance biofilm peptides peptidomimetics AApeptides peptoids |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.02157/full |
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