The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins
The features of Helicobacter pylori adhesins, their interactions with their host counterparts, regulated and selective gene expressions are amongst the many clever strategies this microorganism undertakes to survive the otherwise sterile gastric milieu. The ingenious crafting of these interactions a...
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| Format: | Article |
| Language: | English |
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Pasteur Institute of Iran
2014-01-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
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| Online Access: | http://jommid.pasteur.ac.ir/article-1-44-en.html |
| _version_ | 1819170445968015360 |
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| author | Marjan Mohammadi |
| author_facet | Marjan Mohammadi |
| author_sort | Marjan Mohammadi |
| collection | DOAJ |
| description | The features of Helicobacter pylori adhesins, their interactions with their host counterparts, regulated and selective gene expressions are amongst the many clever strategies this microorganism undertakes to survive the otherwise sterile gastric milieu. The ingenious crafting of these interactions and the respective host reactions govern, in part, an array of consequences ranging from asymptomatic infections to varying degrees of gastric inflammation, ulcer formation, atrophic, metaplastic and dysplastic changes and ultimately gastric cancer. The most well studied H. pylori adhesins include those which bind host blood group antigens namely BabA and SabA. In this review, I attempt to tell the historical tale of how these moieties and their respective interactions with the host were discovered and characterized. The details of the subsequent applications of these findings in further genotyping studies will be later reviewed to avoid disruption of this crafty tale. J Med Microbiol Infec Dis, 2014, 1 (2): 5 pages. |
| first_indexed | 2024-12-22T19:35:31Z |
| format | Article |
| id | doaj.art-9093518d9dc14a8dbdb615207381ed75 |
| institution | Directory Open Access Journal |
| issn | 2345-5349 2345-5330 |
| language | English |
| last_indexed | 2024-12-22T19:35:31Z |
| publishDate | 2014-01-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Journal of Medical Microbiology and Infectious Diseases |
| spelling | doaj.art-9093518d9dc14a8dbdb615207381ed752022-12-21T18:14:59ZengPasteur Institute of IranJournal of Medical Microbiology and Infectious Diseases2345-53492345-53302014-01-01211115The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding ProteinsMarjan Mohammadi0 HPGC Group, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran The features of Helicobacter pylori adhesins, their interactions with their host counterparts, regulated and selective gene expressions are amongst the many clever strategies this microorganism undertakes to survive the otherwise sterile gastric milieu. The ingenious crafting of these interactions and the respective host reactions govern, in part, an array of consequences ranging from asymptomatic infections to varying degrees of gastric inflammation, ulcer formation, atrophic, metaplastic and dysplastic changes and ultimately gastric cancer. The most well studied H. pylori adhesins include those which bind host blood group antigens namely BabA and SabA. In this review, I attempt to tell the historical tale of how these moieties and their respective interactions with the host were discovered and characterized. The details of the subsequent applications of these findings in further genotyping studies will be later reviewed to avoid disruption of this crafty tale. J Med Microbiol Infec Dis, 2014, 1 (2): 5 pages.http://jommid.pasteur.ac.ir/article-1-44-en.htmlbabasabalewis antigen |
| spellingShingle | Marjan Mohammadi The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins Journal of Medical Microbiology and Infectious Diseases baba saba lewis antigen |
| title | The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins |
| title_full | The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins |
| title_fullStr | The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins |
| title_full_unstemmed | The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins |
| title_short | The Tall Tale of the Helicobacter pylori Blood Group Antigen Binding Proteins |
| title_sort | tall tale of the helicobacter pylori blood group antigen binding proteins |
| topic | baba saba lewis antigen |
| url | http://jommid.pasteur.ac.ir/article-1-44-en.html |
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