Natural Steroidal Lactone Induces G1/S Phase Cell Cycle Arrest and Intrinsic Apoptotic Pathway by Up-Regulating Tumor Suppressive miRNA in Triple-Negative Breast Cancer Cells

Natural Steroidal Lactone Induces G1/S Phase Cell Cycle Arrest and Intrinsic Apoptotic Pathway by Up-Regulating Tumor Suppressive miRNA in Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with minimal treatment options. In the present work, Withaferin A (WA), a natural steroidal lactone found in <i>Withania somnifera</i> (Solanaceae), was studied to deduce the miRNA expression modulation mediat...

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Bibliographic Details
Main Authors: Mohd Shuaib, Kumari Sunita Prajapati, Sanjay Gupta, Shashank Kumar
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Metabolites
Subjects:
Withania A
anticancer
apoptosis
phytochemical
MiRNA
sequencing
Online Access:https://www.mdpi.com/2218-1989/13/1/29

Internet

https://www.mdpi.com/2218-1989/13/1/29

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