Development and progression of cancer cachexia: Perspectives from bench to bedside
Cancer cachexia (CC) is a devastating syndrome characterized by weight loss, reduced fat mass and muscle mass that affects approximately 80% of cancer patients and is responsible for 22%–30% of cancer-associated deaths. Understanding underlying mechanisms for the development of CC are crucial to adv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2020-12-01
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| Series: | Sports Medicine and Health Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666337620300664 |
| _version_ | 1819068686287241216 |
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| author | Seongkyun Lim Jacob L. Brown Tyrone A. Washington Nicholas P. Greene |
| author_facet | Seongkyun Lim Jacob L. Brown Tyrone A. Washington Nicholas P. Greene |
| author_sort | Seongkyun Lim |
| collection | DOAJ |
| description | Cancer cachexia (CC) is a devastating syndrome characterized by weight loss, reduced fat mass and muscle mass that affects approximately 80% of cancer patients and is responsible for 22%–30% of cancer-associated deaths. Understanding underlying mechanisms for the development of CC are crucial to advance therapies to treat CC and improve cancer outcomes. CC is a multi-organ syndrome that results in extensive skeletal muscle and adipose tissue wasting; however, CC can impair other organs such as the liver, heart, brain, and bone as well. A considerable amount of CC research focuses on changes that occur within the muscle, but cancer-related impairments in other organ systems are understudied. Furthermore, metabolic changes in organ systems other than muscle may contribute to CC. Therefore, the purpose of this review is to address degenerative mechanisms which occur during CC from a whole-body perspective. Outlining the information known about metabolic changes that occur in response to cancer is necessary to develop and enhance therapies to treat CC. As much of the current evidences in CC are from pre-clinical models we should note the majority of the data reviewed here are from pre-clinical models. |
| first_indexed | 2024-12-21T16:38:05Z |
| format | Article |
| id | doaj.art-90957d7a97bd47708ca3a0992c4f9012 |
| institution | Directory Open Access Journal |
| issn | 2666-3376 |
| language | English |
| last_indexed | 2024-12-21T16:38:05Z |
| publishDate | 2020-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sports Medicine and Health Science |
| spelling | doaj.art-90957d7a97bd47708ca3a0992c4f90122022-12-21T18:57:11ZengKeAi Communications Co., Ltd.Sports Medicine and Health Science2666-33762020-12-0124177185Development and progression of cancer cachexia: Perspectives from bench to bedsideSeongkyun Lim0Jacob L. Brown1Tyrone A. Washington2Nicholas P. Greene3Cachexia Research Laboratory, Exercise Science Research Center, Department of Human Health Performance and Recreation, University of Arkansas, 155 Stadium Dr, Fayetteville, AR, USAAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, USAExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Human Health Performance and Recreation, University of Arkansas, 155 Stadium Dr, Fayetteville, AR, USACachexia Research Laboratory, Exercise Science Research Center, Department of Human Health Performance and Recreation, University of Arkansas, 155 Stadium Dr, Fayetteville, AR, USA; Corresponding author. HPER 321X, University of Arkansas, 155 Stadium Dr, Fayetteville, AR, 72701, USA.Cancer cachexia (CC) is a devastating syndrome characterized by weight loss, reduced fat mass and muscle mass that affects approximately 80% of cancer patients and is responsible for 22%–30% of cancer-associated deaths. Understanding underlying mechanisms for the development of CC are crucial to advance therapies to treat CC and improve cancer outcomes. CC is a multi-organ syndrome that results in extensive skeletal muscle and adipose tissue wasting; however, CC can impair other organs such as the liver, heart, brain, and bone as well. A considerable amount of CC research focuses on changes that occur within the muscle, but cancer-related impairments in other organ systems are understudied. Furthermore, metabolic changes in organ systems other than muscle may contribute to CC. Therefore, the purpose of this review is to address degenerative mechanisms which occur during CC from a whole-body perspective. Outlining the information known about metabolic changes that occur in response to cancer is necessary to develop and enhance therapies to treat CC. As much of the current evidences in CC are from pre-clinical models we should note the majority of the data reviewed here are from pre-clinical models.http://www.sciencedirect.com/science/article/pii/S2666337620300664Muscle atrophyTumor-bearing mouseLewis lung carcinomaProtein turnoverMitochondrial dysfunction |
| spellingShingle | Seongkyun Lim Jacob L. Brown Tyrone A. Washington Nicholas P. Greene Development and progression of cancer cachexia: Perspectives from bench to bedside Sports Medicine and Health Science Muscle atrophy Tumor-bearing mouse Lewis lung carcinoma Protein turnover Mitochondrial dysfunction |
| title | Development and progression of cancer cachexia: Perspectives from bench to bedside |
| title_full | Development and progression of cancer cachexia: Perspectives from bench to bedside |
| title_fullStr | Development and progression of cancer cachexia: Perspectives from bench to bedside |
| title_full_unstemmed | Development and progression of cancer cachexia: Perspectives from bench to bedside |
| title_short | Development and progression of cancer cachexia: Perspectives from bench to bedside |
| title_sort | development and progression of cancer cachexia perspectives from bench to bedside |
| topic | Muscle atrophy Tumor-bearing mouse Lewis lung carcinoma Protein turnover Mitochondrial dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2666337620300664 |
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