Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors

Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible and has caused a pandemic named coronavirus disease 2019 (COVID-19), which has quickly spread worldwide. Although several therapeutic agents have been evaluated or approved for the treatment of C...

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Bibliographic Details
Main Authors: Gangan Yan, Dongsheng Li, Yuan Lin, Zhenghao Fu, Haiyan Qi, Xiaoping Liu, Jing Zhang, Shuyi Si, Yunyu Chen
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Cell & Bioscience
Subjects:
SARS-CoV-2
Main protease inhibitor
3CL protease inhibitor
Fluorescence polarization
High-throughput screening
Dieckol
Online Access:https://doi.org/10.1186/s13578-021-00720-3

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