α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors

α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors

Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a more pronounced antitumor effect. Here, we sh...

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Bibliographic Details
Main Authors: Alexey V. Osipov, Tatiana I. Terpinskaya, Tatsiana Yanchanka, Tatjana Balashevich, Maxim N. Zhmak, Victor I. Tsetlin, Yuri N. Utkin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Marine Drugs
Subjects:
cyclooxygenase
Ehrlich carcinoma
inhibitors
lipoxygenase
α-conotoxin
Online Access:https://www.mdpi.com/1660-3397/18/4/193

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