Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells

Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells

ABSTRACT Zika virus (ZIKV) is unique among mosquito-borne flaviviruses in its ability to be sexually transmitted. Persistent ZIKV infection in the testes, which are immune privileged organs, long after peripheral clearance suggests involvement of immunosuppressive pathways; however, the underlying m...

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Bibliographic Details
Main Authors: Daniel P. Strange, Boonyanudh Jiyarom, Nima Pourhabibi Zarandi, Xuping Xie, Coleman Baker, Hooman Sadri-Ardekani, Pei-Yong Shi, Saguna Verma
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
Axl receptor tyrosine kinase
Sertoli cells
Zika virus
interferon signaling
testes
testicular organoids
Online Access:https://journals.asm.org/doi/10.1128/mBio.01372-19

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