Occupational risk of tuberculosis transmission in a low incidence area
<p>Abstract</p> <p>Background</p> <p>To investigate the occupational risk of tuberculosis (TB) infection in a low-incidence setting, data from a prospective study of patients with culture-confirmed TB conducted in Hamburg, Germany, from 1997 to 2002 were evaluated.</...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-04-01
|
| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://respiratory-research.com/content/6/1/35 |
| _version_ | 1811277462957457408 |
|---|---|
| author | Rüsch-Gerdes Sabine Nienhaus Albert Seidler Andreas Diel Roland Niemann Stefan |
| author_facet | Rüsch-Gerdes Sabine Nienhaus Albert Seidler Andreas Diel Roland Niemann Stefan |
| author_sort | Rüsch-Gerdes Sabine |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To investigate the occupational risk of tuberculosis (TB) infection in a low-incidence setting, data from a prospective study of patients with culture-confirmed TB conducted in Hamburg, Germany, from 1997 to 2002 were evaluated.</p> <p>Methods</p> <p><it>M. tuberculosis </it>isolates were genotyped by IS<it>6110 </it>RFLP analysis. Results of contact tracing and additional patient interviews were used for further epidemiological analyses.</p> <p>Results</p> <p>Out of 848 cases included in the cluster analysis, 286 (33.7%) were classified into 76 clusters comprising 2 to 39 patients. In total, two patients in the non-cluster and eight patients in the cluster group were health-care workers. Logistic regression analysis confirmed work in the health-care sector as the strongest predictor for clustering (OR 17.9). However, only two of the eight transmission links among the eight clusters involving health-care workers had been detected previously. Overall, conventional contact tracing performed before genotyping had identified only 26 (25.2%) of the 103 contact persons with the disease among the clustered cases whose transmission links were epidemiologically verified.</p> <p>Conclusion</p> <p>Recent transmission was found to be strongly associated with health-care work in a setting with low incidence of TB. Conventional contact tracing alone was shown to be insufficient to discover recent transmission chains. The data presented also indicate the need for establishing improved TB control strategies in health-care settings.</p> |
| first_indexed | 2024-04-13T00:17:00Z |
| format | Article |
| id | doaj.art-909954f0d50d4dd2b1799b5089fa9339 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-04-13T00:17:00Z |
| publishDate | 2005-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-909954f0d50d4dd2b1799b5089fa93392022-12-22T03:10:55ZengBMCRespiratory Research1465-99212005-04-01613510.1186/1465-9921-6-35Occupational risk of tuberculosis transmission in a low incidence areaRüsch-Gerdes SabineNienhaus AlbertSeidler AndreasDiel RolandNiemann Stefan<p>Abstract</p> <p>Background</p> <p>To investigate the occupational risk of tuberculosis (TB) infection in a low-incidence setting, data from a prospective study of patients with culture-confirmed TB conducted in Hamburg, Germany, from 1997 to 2002 were evaluated.</p> <p>Methods</p> <p><it>M. tuberculosis </it>isolates were genotyped by IS<it>6110 </it>RFLP analysis. Results of contact tracing and additional patient interviews were used for further epidemiological analyses.</p> <p>Results</p> <p>Out of 848 cases included in the cluster analysis, 286 (33.7%) were classified into 76 clusters comprising 2 to 39 patients. In total, two patients in the non-cluster and eight patients in the cluster group were health-care workers. Logistic regression analysis confirmed work in the health-care sector as the strongest predictor for clustering (OR 17.9). However, only two of the eight transmission links among the eight clusters involving health-care workers had been detected previously. Overall, conventional contact tracing performed before genotyping had identified only 26 (25.2%) of the 103 contact persons with the disease among the clustered cases whose transmission links were epidemiologically verified.</p> <p>Conclusion</p> <p>Recent transmission was found to be strongly associated with health-care work in a setting with low incidence of TB. Conventional contact tracing alone was shown to be insufficient to discover recent transmission chains. The data presented also indicate the need for establishing improved TB control strategies in health-care settings.</p>http://respiratory-research.com/content/6/1/35tuberculosis epidemiology |
| spellingShingle | Rüsch-Gerdes Sabine Nienhaus Albert Seidler Andreas Diel Roland Niemann Stefan Occupational risk of tuberculosis transmission in a low incidence area Respiratory Research tuberculosis epidemiology |
| title | Occupational risk of tuberculosis transmission in a low incidence area |
| title_full | Occupational risk of tuberculosis transmission in a low incidence area |
| title_fullStr | Occupational risk of tuberculosis transmission in a low incidence area |
| title_full_unstemmed | Occupational risk of tuberculosis transmission in a low incidence area |
| title_short | Occupational risk of tuberculosis transmission in a low incidence area |
| title_sort | occupational risk of tuberculosis transmission in a low incidence area |
| topic | tuberculosis epidemiology |
| url | http://respiratory-research.com/content/6/1/35 |
| work_keys_str_mv | AT ruschgerdessabine occupationalriskoftuberculosistransmissioninalowincidencearea AT nienhausalbert occupationalriskoftuberculosistransmissioninalowincidencearea AT seidlerandreas occupationalriskoftuberculosistransmissioninalowincidencearea AT dielroland occupationalriskoftuberculosistransmissioninalowincidencearea AT niemannstefan occupationalriskoftuberculosistransmissioninalowincidencearea |