Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT)
Abstract Introduction: Diabetes mellitus in underrepresented racial and ethnic groups (URG) is rapidly increasing in incidence and has worse outcomes than diabetes in non-Hispanic White individuals. Rare and Atypical Diabetes Network (RADIANT) established recruitment targets based on the racial an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-01-01
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| Series: | Journal of Clinical and Translational Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866122005295/type/journal_article |
| _version_ | 1811156503518773248 |
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| author | Mustafa Tosur Laura Gandolfo Ashok Balasubramanyam Rochelle N. Naylor Toni I. Pollin Neda Rasouli Sara J. Cromer John B. Buse Maria J. Redondo RADIANT Study Group |
| author_facet | Mustafa Tosur Laura Gandolfo Ashok Balasubramanyam Rochelle N. Naylor Toni I. Pollin Neda Rasouli Sara J. Cromer John B. Buse Maria J. Redondo RADIANT Study Group |
| author_sort | Mustafa Tosur |
| collection | DOAJ |
| description |
Abstract
Introduction:
Diabetes mellitus in underrepresented racial and ethnic groups (URG) is rapidly increasing in incidence and has worse outcomes than diabetes in non-Hispanic White individuals. Rare and Atypical Diabetes Network (RADIANT) established recruitment targets based on the racial and ethnic distribution of the USA to enroll a diverse study population. We examined participation of URG across RADIANT study stages and described strategies to enhance recruitment and retention of URG.
Materials and Methods:
RADIANT is a multicenter NIH-funded study of people with uncharacterized forms of atypical diabetes. RADIANT participants consent online and progress through three sequential study stages, as eligible.
Results:
We enrolled 601 participants with mean age 44 ± 16.8 years, 64.4% female. At Stage 1, 80.6% were White, 7.2% African American (AA), 12.2% other/more than one race, and 8.4% Hispanic. Enrollment of URG was significantly below preset targets across most stages. Referral sources differed by race (p < 0.001) but not ethnicity (p = 0.15). Most AA participants were referred by RADIANT investigators (58.5% vs. 24.5% in Whites), whereas flyers, news, social media, and family or friends were more frequent referral sources for White individuals (26.4% vs. 12.2% in AA). Ongoing initiatives to increase enrollment of URG in RADIANT include engaging with clinics/hospitals serving URG, screening electronic medical records, and providing culturally competent study coordination and targeted advertisement.
Conclusions:
There is low participation of URG in RADIANT, potentially limiting the generalizability of its discoveries. Investigations into barriers and facilitators for recruitment and retention of URG in RADIANT, with implications for other studies, are ongoing.
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| first_indexed | 2024-04-10T04:52:49Z |
| format | Article |
| id | doaj.art-909e7188a55f47e3b112de37f19c358e |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:52:49Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-909e7188a55f47e3b112de37f19c358e2023-03-09T12:31:13ZengCambridge University PressJournal of Clinical and Translational Science2059-86612023-01-01710.1017/cts.2022.529Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT)Mustafa Tosur0https://orcid.org/0000-0002-2111-271XLaura Gandolfo1Ashok Balasubramanyam2Rochelle N. Naylor3Toni I. Pollin4Neda Rasouli5Sara J. Cromer6John B. Buse7https://orcid.org/0000-0002-9723-3876Maria J. Redondo8RADIANT Study GroupDepartment of Pediatrics, The Division of Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA Children’s Nutrition Research Center, USDA/ARS, Houston, TX, USAHealth Informatics Institute, University of South Florida, Tampa, FL, USADivision of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USADivision of Adult and Pediatric Endocrinology Diabetes, and Metabolism, Departments of Pediatrics and Medicine, University of Chicago, Chicago, IL, USADepartments of Medicine and Epidemiology & Public Health, University of Maryland, Baltimore, MD, USADivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, CO, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USADivision of Endocrinology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USADepartment of Pediatrics, The Division of Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA Abstract Introduction: Diabetes mellitus in underrepresented racial and ethnic groups (URG) is rapidly increasing in incidence and has worse outcomes than diabetes in non-Hispanic White individuals. Rare and Atypical Diabetes Network (RADIANT) established recruitment targets based on the racial and ethnic distribution of the USA to enroll a diverse study population. We examined participation of URG across RADIANT study stages and described strategies to enhance recruitment and retention of URG. Materials and Methods: RADIANT is a multicenter NIH-funded study of people with uncharacterized forms of atypical diabetes. RADIANT participants consent online and progress through three sequential study stages, as eligible. Results: We enrolled 601 participants with mean age 44 ± 16.8 years, 64.4% female. At Stage 1, 80.6% were White, 7.2% African American (AA), 12.2% other/more than one race, and 8.4% Hispanic. Enrollment of URG was significantly below preset targets across most stages. Referral sources differed by race (p < 0.001) but not ethnicity (p = 0.15). Most AA participants were referred by RADIANT investigators (58.5% vs. 24.5% in Whites), whereas flyers, news, social media, and family or friends were more frequent referral sources for White individuals (26.4% vs. 12.2% in AA). Ongoing initiatives to increase enrollment of URG in RADIANT include engaging with clinics/hospitals serving URG, screening electronic medical records, and providing culturally competent study coordination and targeted advertisement. Conclusions: There is low participation of URG in RADIANT, potentially limiting the generalizability of its discoveries. Investigations into barriers and facilitators for recruitment and retention of URG in RADIANT, with implications for other studies, are ongoing. https://www.cambridge.org/core/product/identifier/S2059866122005295/type/journal_articleRaceethnicityhispanic ethnicityAfrican American raceclinical research |
| spellingShingle | Mustafa Tosur Laura Gandolfo Ashok Balasubramanyam Rochelle N. Naylor Toni I. Pollin Neda Rasouli Sara J. Cromer John B. Buse Maria J. Redondo RADIANT Study Group Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT) Journal of Clinical and Translational Science Race ethnicity hispanic ethnicity African American race clinical research |
| title | Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT) |
| title_full | Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT) |
| title_fullStr | Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT) |
| title_full_unstemmed | Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT) |
| title_short | Enrollment of underrepresented racial and ethnic groups in the Rare and Atypical Diabetes Network (RADIANT) |
| title_sort | enrollment of underrepresented racial and ethnic groups in the rare and atypical diabetes network radiant |
| topic | Race ethnicity hispanic ethnicity African American race clinical research |
| url | https://www.cambridge.org/core/product/identifier/S2059866122005295/type/journal_article |
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