The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells

The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells

The Nrf2 anti-oxidant response element (ARE) pathway plays an important role in regulating cellular anti-oxidants. Under normal cellular conditions Nrf2 can be described as an anti-tumor molecule due to its induction of cytoprotective genes which protect cells from electrophile and oxidative damage....

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Bibliographic Details
Main Authors:	David J. MacEwan, Stuart A. Rushworth
Format:	Article
Language:	English
Published:	MDPI AG 2011-03-01
Series:	Cancers
Subjects:	leukemia AML CLL apoptosis transcription factor Nrf2, antioxidant HO-1 NQO1 glutathione chemotherapy NF-κB acute myeloid leukemia
Online Access:	http://www.mdpi.com/2072-6694/3/2/1605/

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