Regional difference in the susceptibility of non-alcoholic fatty liver disease in China
Introduction Non-alcoholic fatty liver disease (NAFLD) is a global health problem with high geographic heterogeneity. We aimed to investigate regional-specific concomitant rate of NAFLD and quantitative relationship between liver fat content (LFC) and glucose metabolism parameters in representative...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-04-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/8/1/e001311.full |
| _version_ | 1819063356080783360 |
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| author | Lanjie He Mingfeng Xia Xiaoyang Sun Lili Zheng Fusheng Di Yanyan Gao Bingjie Wu Hua Bian |
| author_facet | Lanjie He Mingfeng Xia Xiaoyang Sun Lili Zheng Fusheng Di Yanyan Gao Bingjie Wu Hua Bian |
| author_sort | Lanjie He |
| collection | DOAJ |
| description | Introduction Non-alcoholic fatty liver disease (NAFLD) is a global health problem with high geographic heterogeneity. We aimed to investigate regional-specific concomitant rate of NAFLD and quantitative relationship between liver fat content (LFC) and glucose metabolism parameters in representative clinical populations from six provinces/municipalities of China.Research design and methods A total of 2420 eligible Han Chinese were enrolled consecutively from 10 clinics of obesity, diabetes and metabolic diseases located at six provinces/municipalities of China, and divided into North (Tianjin, Shandong and Heilongjiang) and South (Shanghai, Jiangsu and Henan) groups according to their geographical latitude and proximity of NAFLD concomitant rate. LFC was assessed by a quantitative ultrasound method. Multivariate regression models and analysis of covariance were used to assess the regional difference in the risk of NAFLD.Results The concomitant rate of NAFLD was 23.3%, 44.0% and 55.3% in individuals with normal glucose tolerance (NGT), pre-diabetes and diabetes, respectively. A higher concomitant rate of NAFLD was found in the participants from the North comparing with the South group, regardless of glucose metabolism status (34.7% vs 16.2% in NGT, 61.5% vs 34.7% in pre-diabetes and 67.1% vs 48.1% in diabetes). This regional difference remained significant after adjustment for age, gender, alcohol drinking, cigarette smoking, confounding metabolic parameters and liver enzymes. For any given blood glucose, participants from the North had higher LFC than those from the South group.Conclusions Half of Han Chinese with pre-diabetes/type 2 diabetes had NAFLD, and the individuals from the North cities were more susceptible to NAFLD. |
| first_indexed | 2024-12-21T15:13:22Z |
| format | Article |
| id | doaj.art-909f26aa8bb242f7a15beb1c16799553 |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-12-21T15:13:22Z |
| publishDate | 2020-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-909f26aa8bb242f7a15beb1c167995532022-12-21T18:59:14ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972020-04-018110.1136/bmjdrc-2020-001311Regional difference in the susceptibility of non-alcoholic fatty liver disease in ChinaLanjie He0Mingfeng Xia1Xiaoyang Sun2Lili Zheng3Fusheng Di4Yanyan Gao5Bingjie Wu6Hua Bian7Endocrine Testing Center, General Hospital of Ningxia Medical University, Yinchuan, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Disease, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Endocrinology and Metabolism, The Third Central Hospital of Tianjin, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Medical College, Qingdao University, Qingdao, ChinaDepartment of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Disease, Fudan University, Shanghai, ChinaIntroduction Non-alcoholic fatty liver disease (NAFLD) is a global health problem with high geographic heterogeneity. We aimed to investigate regional-specific concomitant rate of NAFLD and quantitative relationship between liver fat content (LFC) and glucose metabolism parameters in representative clinical populations from six provinces/municipalities of China.Research design and methods A total of 2420 eligible Han Chinese were enrolled consecutively from 10 clinics of obesity, diabetes and metabolic diseases located at six provinces/municipalities of China, and divided into North (Tianjin, Shandong and Heilongjiang) and South (Shanghai, Jiangsu and Henan) groups according to their geographical latitude and proximity of NAFLD concomitant rate. LFC was assessed by a quantitative ultrasound method. Multivariate regression models and analysis of covariance were used to assess the regional difference in the risk of NAFLD.Results The concomitant rate of NAFLD was 23.3%, 44.0% and 55.3% in individuals with normal glucose tolerance (NGT), pre-diabetes and diabetes, respectively. A higher concomitant rate of NAFLD was found in the participants from the North comparing with the South group, regardless of glucose metabolism status (34.7% vs 16.2% in NGT, 61.5% vs 34.7% in pre-diabetes and 67.1% vs 48.1% in diabetes). This regional difference remained significant after adjustment for age, gender, alcohol drinking, cigarette smoking, confounding metabolic parameters and liver enzymes. For any given blood glucose, participants from the North had higher LFC than those from the South group.Conclusions Half of Han Chinese with pre-diabetes/type 2 diabetes had NAFLD, and the individuals from the North cities were more susceptible to NAFLD.https://drc.bmj.com/content/8/1/e001311.full |
| spellingShingle | Lanjie He Mingfeng Xia Xiaoyang Sun Lili Zheng Fusheng Di Yanyan Gao Bingjie Wu Hua Bian Regional difference in the susceptibility of non-alcoholic fatty liver disease in China BMJ Open Diabetes Research & Care |
| title | Regional difference in the susceptibility of non-alcoholic fatty liver disease in China |
| title_full | Regional difference in the susceptibility of non-alcoholic fatty liver disease in China |
| title_fullStr | Regional difference in the susceptibility of non-alcoholic fatty liver disease in China |
| title_full_unstemmed | Regional difference in the susceptibility of non-alcoholic fatty liver disease in China |
| title_short | Regional difference in the susceptibility of non-alcoholic fatty liver disease in China |
| title_sort | regional difference in the susceptibility of non alcoholic fatty liver disease in china |
| url | https://drc.bmj.com/content/8/1/e001311.full |
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