Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile
Influenza A viruses occur worldwide in wild birds and are occasionally associated with outbreaks in commercial chickens and turkeys. However, avian influenza viruses have not been isolated from wild birds or poultry in South America. A recent outbreak in chickens of H7N3 low pathogenic avian influen...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2004-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/10/4/03-0396_article |
| _version_ | 1811288197846532096 |
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| author | David L. Suarez Dennis A. Senne Jill Banks Ian H. Brown Steve C. Essen Chang-Won Lee Ruth J. Manvell Christian Mathieu-Benson Valentine Moreno Janice C. Pedersen Brundaban Panigrahy Herman Rojas Eric Spackman Dennis J. Alexander |
| author_facet | David L. Suarez Dennis A. Senne Jill Banks Ian H. Brown Steve C. Essen Chang-Won Lee Ruth J. Manvell Christian Mathieu-Benson Valentine Moreno Janice C. Pedersen Brundaban Panigrahy Herman Rojas Eric Spackman Dennis J. Alexander |
| author_sort | David L. Suarez |
| collection | DOAJ |
| description | Influenza A viruses occur worldwide in wild birds and are occasionally associated with outbreaks in commercial chickens and turkeys. However, avian influenza viruses have not been isolated from wild birds or poultry in South America. A recent outbreak in chickens of H7N3 low pathogenic avian influenza (LPAI) occurred in Chile. One month later, after a sudden increase in deaths, H7N3 highly pathogenic avian influenza (HPAI) virus was isolated. Sequence analysis of all eight genes of the LPAI virus and the HPAI viruses showed minor differences between the viruses except at the hemagglutinin (HA) cleavage site. The LPAI virus had a cleavage site similar to other low pathogenic H7 viruses, but the HPAI isolates had a 30 nucleotide insert. The insertion likely occurred by recombination between the HA and nucleoprotein genes of the LPAI virus, resulting in a virulence shift. Sequence comparison of all eight gene segments showed the Chilean viruses were also distinct from all other avian influenza viruses and represent a distinct South American clade. |
| first_indexed | 2024-04-13T03:32:47Z |
| format | Article |
| id | doaj.art-90a14dec4f9947988f83ebf39d79ec8b |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-13T03:32:47Z |
| publishDate | 2004-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-90a14dec4f9947988f83ebf39d79ec8b2022-12-22T03:04:26ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-04-0110469369910.3201/eid1004.030396Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, ChileDavid L. SuarezDennis A. SenneJill BanksIan H. BrownSteve C. EssenChang-Won LeeRuth J. ManvellChristian Mathieu-BensonValentine MorenoJanice C. PedersenBrundaban PanigrahyHerman RojasEric SpackmanDennis J. AlexanderInfluenza A viruses occur worldwide in wild birds and are occasionally associated with outbreaks in commercial chickens and turkeys. However, avian influenza viruses have not been isolated from wild birds or poultry in South America. A recent outbreak in chickens of H7N3 low pathogenic avian influenza (LPAI) occurred in Chile. One month later, after a sudden increase in deaths, H7N3 highly pathogenic avian influenza (HPAI) virus was isolated. Sequence analysis of all eight genes of the LPAI virus and the HPAI viruses showed minor differences between the viruses except at the hemagglutinin (HA) cleavage site. The LPAI virus had a cleavage site similar to other low pathogenic H7 viruses, but the HPAI isolates had a 30 nucleotide insert. The insertion likely occurred by recombination between the HA and nucleoprotein genes of the LPAI virus, resulting in a virulence shift. Sequence comparison of all eight gene segments showed the Chilean viruses were also distinct from all other avian influenza viruses and represent a distinct South American clade.https://wwwnc.cdc.gov/eid/article/10/4/03-0396_articleInfluenzapoultryorthomyxoviridae infectionsChile |
| spellingShingle | David L. Suarez Dennis A. Senne Jill Banks Ian H. Brown Steve C. Essen Chang-Won Lee Ruth J. Manvell Christian Mathieu-Benson Valentine Moreno Janice C. Pedersen Brundaban Panigrahy Herman Rojas Eric Spackman Dennis J. Alexander Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile Emerging Infectious Diseases Influenza poultry orthomyxoviridae infections Chile |
| title | Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile |
| title_full | Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile |
| title_fullStr | Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile |
| title_full_unstemmed | Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile |
| title_short | Recombination Resulting in Virulence Shift in Avian Influenza Outbreak, Chile |
| title_sort | recombination resulting in virulence shift in avian influenza outbreak chile |
| topic | Influenza poultry orthomyxoviridae infections Chile |
| url | https://wwwnc.cdc.gov/eid/article/10/4/03-0396_article |
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