Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia

Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia

Dopamine replacement therapy for Parkinson’s disease is achieved using L-DOPA or dopamine D2/3 agonists, such as ropinirole. Here, we compare the effects of L-DOPA and ropinirole, alone or in combination, on patterns of glial and microvascular reactivity in the striatum. Rats with unilateral 6-hydro...

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Bibliographic Details
Main Authors: Osama F. Elabi, Elena Espa, Katrine Skovgård, Silvia Fanni, Maria Angela Cenci
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
levodopa-induced dyskinesia
dopamine agonist
neuroinflammation
Online Access:https://www.mdpi.com/2073-4409/12/14/1859

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