Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail

Abstract Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol suppleme...

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Main Authors: Shabnam Nikniaz, Farzane Vaziri, Reza Mansouri
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Oral Health
Subjects:
Online Access:https://doi.org/10.1186/s12903-023-02877-4
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author Shabnam Nikniaz
Farzane Vaziri
Reza Mansouri
author_facet Shabnam Nikniaz
Farzane Vaziri
Reza Mansouri
author_sort Shabnam Nikniaz
collection DOAJ
description Abstract Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis. Methods In this randomized, double-blind study, 40 chronic periodontitis patients underwent non-surgical therapy and were randomly assigned to two intervention and control groups, receiving either resveratrol supplements or a placebo for four weeks. Salivary levels of interleukin-8 (IL-8), interleukin-1β (IL-1β), and clinical parameters, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured before and after the intervention. Results The results showed that in both the case and control groups, after four weeks of using resveratrol, only plaque index (PI) was significantly different compared to the control group (P = 0.0001). However, there were no significant differences in the mean pocket depth (PD), clinical attachment loss (CAL), bleeding index (BI), and salivary levels of IL-8 and IL-1β between the two groups after the intervention. Conclusion Resveratrol complement was helpful as an anti-inflammatory food supplement, along with other non-surgical periodontal treatments in chronic periodontitis patients.
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spelling doaj.art-90a1e462cf2d4f1a904b5412712124572023-04-03T05:42:51ZengBMCBMC Oral Health1472-68312023-03-012311710.1186/s12903-023-02877-4Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trailShabnam Nikniaz0Farzane Vaziri1Reza Mansouri2Department of Periodontics, School of Dentistry, Shahid Sadoughi University of Medical SciencesDepartment of Periodontics, School of Dentistry, Shahid Sadoughi University of Medical SciencesDepartment of Immunology, faculty of medicine, Shahid Sadoughi University of Medical SciencesAbstract Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis. Methods In this randomized, double-blind study, 40 chronic periodontitis patients underwent non-surgical therapy and were randomly assigned to two intervention and control groups, receiving either resveratrol supplements or a placebo for four weeks. Salivary levels of interleukin-8 (IL-8), interleukin-1β (IL-1β), and clinical parameters, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured before and after the intervention. Results The results showed that in both the case and control groups, after four weeks of using resveratrol, only plaque index (PI) was significantly different compared to the control group (P = 0.0001). However, there were no significant differences in the mean pocket depth (PD), clinical attachment loss (CAL), bleeding index (BI), and salivary levels of IL-8 and IL-1β between the two groups after the intervention. Conclusion Resveratrol complement was helpful as an anti-inflammatory food supplement, along with other non-surgical periodontal treatments in chronic periodontitis patients.https://doi.org/10.1186/s12903-023-02877-4Chronic periodontitisPolyphenolDietary supplementationResveratrol
spellingShingle Shabnam Nikniaz
Farzane Vaziri
Reza Mansouri
Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
BMC Oral Health
Chronic periodontitis
Polyphenol
Dietary supplementation
Resveratrol
title Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
title_full Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
title_fullStr Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
title_full_unstemmed Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
title_short Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
title_sort impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis a randomized clinical trail
topic Chronic periodontitis
Polyphenol
Dietary supplementation
Resveratrol
url https://doi.org/10.1186/s12903-023-02877-4
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AT rezamansouri impactofresveratrolsupplementationonclinicalparametersandinflammatorymarkersinpatientswithchronicperiodontitisarandomizedclinicaltrail