Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail
Abstract Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol suppleme...
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Format: | Article |
Language: | English |
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BMC
2023-03-01
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Series: | BMC Oral Health |
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Online Access: | https://doi.org/10.1186/s12903-023-02877-4 |
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author | Shabnam Nikniaz Farzane Vaziri Reza Mansouri |
author_facet | Shabnam Nikniaz Farzane Vaziri Reza Mansouri |
author_sort | Shabnam Nikniaz |
collection | DOAJ |
description | Abstract Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis. Methods In this randomized, double-blind study, 40 chronic periodontitis patients underwent non-surgical therapy and were randomly assigned to two intervention and control groups, receiving either resveratrol supplements or a placebo for four weeks. Salivary levels of interleukin-8 (IL-8), interleukin-1β (IL-1β), and clinical parameters, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured before and after the intervention. Results The results showed that in both the case and control groups, after four weeks of using resveratrol, only plaque index (PI) was significantly different compared to the control group (P = 0.0001). However, there were no significant differences in the mean pocket depth (PD), clinical attachment loss (CAL), bleeding index (BI), and salivary levels of IL-8 and IL-1β between the two groups after the intervention. Conclusion Resveratrol complement was helpful as an anti-inflammatory food supplement, along with other non-surgical periodontal treatments in chronic periodontitis patients. |
first_indexed | 2024-04-09T19:52:05Z |
format | Article |
id | doaj.art-90a1e462cf2d4f1a904b541271212457 |
institution | Directory Open Access Journal |
issn | 1472-6831 |
language | English |
last_indexed | 2024-04-09T19:52:05Z |
publishDate | 2023-03-01 |
publisher | BMC |
record_format | Article |
series | BMC Oral Health |
spelling | doaj.art-90a1e462cf2d4f1a904b5412712124572023-04-03T05:42:51ZengBMCBMC Oral Health1472-68312023-03-012311710.1186/s12903-023-02877-4Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trailShabnam Nikniaz0Farzane Vaziri1Reza Mansouri2Department of Periodontics, School of Dentistry, Shahid Sadoughi University of Medical SciencesDepartment of Periodontics, School of Dentistry, Shahid Sadoughi University of Medical SciencesDepartment of Immunology, faculty of medicine, Shahid Sadoughi University of Medical SciencesAbstract Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis. Methods In this randomized, double-blind study, 40 chronic periodontitis patients underwent non-surgical therapy and were randomly assigned to two intervention and control groups, receiving either resveratrol supplements or a placebo for four weeks. Salivary levels of interleukin-8 (IL-8), interleukin-1β (IL-1β), and clinical parameters, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured before and after the intervention. Results The results showed that in both the case and control groups, after four weeks of using resveratrol, only plaque index (PI) was significantly different compared to the control group (P = 0.0001). However, there were no significant differences in the mean pocket depth (PD), clinical attachment loss (CAL), bleeding index (BI), and salivary levels of IL-8 and IL-1β between the two groups after the intervention. Conclusion Resveratrol complement was helpful as an anti-inflammatory food supplement, along with other non-surgical periodontal treatments in chronic periodontitis patients.https://doi.org/10.1186/s12903-023-02877-4Chronic periodontitisPolyphenolDietary supplementationResveratrol |
spellingShingle | Shabnam Nikniaz Farzane Vaziri Reza Mansouri Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail BMC Oral Health Chronic periodontitis Polyphenol Dietary supplementation Resveratrol |
title | Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail |
title_full | Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail |
title_fullStr | Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail |
title_full_unstemmed | Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail |
title_short | Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail |
title_sort | impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis a randomized clinical trail |
topic | Chronic periodontitis Polyphenol Dietary supplementation Resveratrol |
url | https://doi.org/10.1186/s12903-023-02877-4 |
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