Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection
There isaccumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control. Here, we discuss studies suggesting a nutritional strategy for down-regulating ACE2 expression i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2021-02-01
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| Series: | Journal of Tropical Life Science |
| Subjects: | |
| Online Access: | https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1501/pdf |
| _version_ | 1797421269420867584 |
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| author | Custer C. Deocaris Malona V. Alinsug |
| author_facet | Custer C. Deocaris Malona V. Alinsug |
| author_sort | Custer C. Deocaris |
| collection | DOAJ |
| description | There isaccumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control. Here, we discuss studies suggesting a nutritional strategy for down-regulating ACE2 expression in tissues of offspring through the phenom-enon of maternal epigenomic reprogramming mediated by maternal diet. The "thrifty hypothesis" was first proposed by Hales and Barker,which posits that spe-cific genes are programmed based on early-life experience to promote efficient fat deposition and storage in adulthood. Our analysis of the proposed mechanism for "early life programming" in this paper vianutritional modulation of histone acety-lation and DNA methylation goes beyond the physiological consequence of boost-ing the innate cellular resistance to a viral transmission. During the pandemic,where there is still no specific antiviral drug or a widely disseminated vaccine for COVID-19, we hypothesize that an epigenomic nutritionapproachmay be a prac-tical approach to help mitigate viral transmission offspring. |
| first_indexed | 2024-03-09T07:13:30Z |
| format | Article |
| id | doaj.art-90a2dd379bd3476c95018ee04eeb2f45 |
| institution | Directory Open Access Journal |
| issn | 2087-5517 |
| language | English |
| last_indexed | 2024-03-09T07:13:30Z |
| publishDate | 2021-02-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Tropical Life Science |
| spelling | doaj.art-90a2dd379bd3476c95018ee04eeb2f452023-12-03T08:54:26ZengUniversity of BrawijayaJournal of Tropical Life Science2087-55172021-02-011115357http://dx.doi.org/10.11594/jtls.11.01.07Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” ConnectionCuster C. Deocaris0Malona V. Alinsug1Biomedical Research Section, Atomic Research Division, Philippine Nuclear Research Institute, Department of Science and Technology, Commonwealth Avenue, Diliman, Quezon City1101, PhilippinesGraduate Program, Mindanao State University-General Santos City, General Santos City 9500, PhilippinesThere isaccumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control. Here, we discuss studies suggesting a nutritional strategy for down-regulating ACE2 expression in tissues of offspring through the phenom-enon of maternal epigenomic reprogramming mediated by maternal diet. The "thrifty hypothesis" was first proposed by Hales and Barker,which posits that spe-cific genes are programmed based on early-life experience to promote efficient fat deposition and storage in adulthood. Our analysis of the proposed mechanism for "early life programming" in this paper vianutritional modulation of histone acety-lation and DNA methylation goes beyond the physiological consequence of boost-ing the innate cellular resistance to a viral transmission. During the pandemic,where there is still no specific antiviral drug or a widely disseminated vaccine for COVID-19, we hypothesize that an epigenomic nutritionapproachmay be a prac-tical approach to help mitigate viral transmission offspring.https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1501/pdfsars-cov-2covid-19ace2maternal reprogrammingnutrition epigenomicsperinatalplant-based diethigh-fat diet effectsthrifty phenotype hypothesis |
| spellingShingle | Custer C. Deocaris Malona V. Alinsug Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection Journal of Tropical Life Science sars-cov-2 covid-19 ace2 maternal reprogramming nutrition epigenomics perinatal plant-based diet high-fat diet effects thrifty phenotype hypothesis |
| title | Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection |
| title_full | Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection |
| title_fullStr | Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection |
| title_full_unstemmed | Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection |
| title_short | Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection |
| title_sort | maternal diet during pregnancy and covid 19 susceptibility of offspring the thrifty phenotype hypothesis connection |
| topic | sars-cov-2 covid-19 ace2 maternal reprogramming nutrition epigenomics perinatal plant-based diet high-fat diet effects thrifty phenotype hypothesis |
| url | https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1501/pdf |
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