Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application
Nuclear magnetic resonance (NMR)-based metabolomics is a valuable tool for identifying biomarkers and understanding the underlying metabolic changes associated with various diseases. However, the translation of metabolomics analysis to clinical practice has been limited by the high cost and large si...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/13/5/614 |
| _version_ | 1797599142289080320 |
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| author | Pilar Alonso-Moreno Ignacio Rodriguez Jose Luis Izquierdo-Garcia |
| author_facet | Pilar Alonso-Moreno Ignacio Rodriguez Jose Luis Izquierdo-Garcia |
| author_sort | Pilar Alonso-Moreno |
| collection | DOAJ |
| description | Nuclear magnetic resonance (NMR)-based metabolomics is a valuable tool for identifying biomarkers and understanding the underlying metabolic changes associated with various diseases. However, the translation of metabolomics analysis to clinical practice has been limited by the high cost and large size of traditional high-resolution NMR spectrometers. Benchtop NMR, a compact and low-cost alternative, offers the potential to overcome these limitations and facilitate the wider use of NMR-based metabolomics in clinical settings. This review summarizes the current state of benchtop NMR for clinical applications where benchtop NMR has demonstrated the ability to reproducibly detect changes in metabolite levels associated with diseases such as type 2 diabetes and tuberculosis. Benchtop NMR has been used to identify metabolic biomarkers in a range of biofluids, including urine, blood plasma and saliva. However, further research is needed to optimize the use of benchtop NMR for clinical applications and to identify additional biomarkers that can be used to monitor and manage a range of diseases. Overall, benchtop NMR has the potential to revolutionize the way metabolomics is used in clinical practice, providing a more accessible and cost-effective way to study metabolism and identify biomarkers for disease diagnosis, prognosis, and treatment. |
| first_indexed | 2024-03-11T03:30:32Z |
| format | Article |
| id | doaj.art-90a30bff062b4648877e0c44a3b604f1 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T03:30:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-90a30bff062b4648877e0c44a3b604f12023-11-18T02:25:21ZengMDPI AGMetabolites2218-19892023-04-0113561410.3390/metabo13050614Benchtop NMR-Based Metabolomics: First Steps for Biomedical ApplicationPilar Alonso-Moreno0Ignacio Rodriguez1Jose Luis Izquierdo-Garcia2NMR and Imaging in Biomedicine Group, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, SpainNMR and Imaging in Biomedicine Group, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, SpainNMR and Imaging in Biomedicine Group, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, SpainNuclear magnetic resonance (NMR)-based metabolomics is a valuable tool for identifying biomarkers and understanding the underlying metabolic changes associated with various diseases. However, the translation of metabolomics analysis to clinical practice has been limited by the high cost and large size of traditional high-resolution NMR spectrometers. Benchtop NMR, a compact and low-cost alternative, offers the potential to overcome these limitations and facilitate the wider use of NMR-based metabolomics in clinical settings. This review summarizes the current state of benchtop NMR for clinical applications where benchtop NMR has demonstrated the ability to reproducibly detect changes in metabolite levels associated with diseases such as type 2 diabetes and tuberculosis. Benchtop NMR has been used to identify metabolic biomarkers in a range of biofluids, including urine, blood plasma and saliva. However, further research is needed to optimize the use of benchtop NMR for clinical applications and to identify additional biomarkers that can be used to monitor and manage a range of diseases. Overall, benchtop NMR has the potential to revolutionize the way metabolomics is used in clinical practice, providing a more accessible and cost-effective way to study metabolism and identify biomarkers for disease diagnosis, prognosis, and treatment.https://www.mdpi.com/2218-1989/13/5/614nuclear magnetic resonancemetabolomicsbenchtoplow fielddiabetestuberculosis |
| spellingShingle | Pilar Alonso-Moreno Ignacio Rodriguez Jose Luis Izquierdo-Garcia Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application Metabolites nuclear magnetic resonance metabolomics benchtop low field diabetes tuberculosis |
| title | Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application |
| title_full | Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application |
| title_fullStr | Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application |
| title_full_unstemmed | Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application |
| title_short | Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application |
| title_sort | benchtop nmr based metabolomics first steps for biomedical application |
| topic | nuclear magnetic resonance metabolomics benchtop low field diabetes tuberculosis |
| url | https://www.mdpi.com/2218-1989/13/5/614 |
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