Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases
The paper gives the data available in the literature on the role of a level of elevated lipoprotein (a) (Lp (a)) in the development of ischemic stroke and other cardiovascular diseases. It shows the normal level of Lp (a) and the typical distribution of its concentration for people of European origi...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2016-03-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
| Subjects: | |
| Online Access: | https://nnp.ima-press.net/nnp/article/view/589 |
| _version_ | 1797876438026682368 |
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| author | N. A. Pizov N. V. Pizova |
| author_facet | N. A. Pizov N. V. Pizova |
| author_sort | N. A. Pizov |
| collection | DOAJ |
| description | The paper gives the data available in the literature on the role of a level of elevated lipoprotein (a) (Lp (a)) in the development of ischemic stroke and other cardiovascular diseases. It shows the normal level of Lp (a) and the typical distribution of its concentration for people of European origin and representatives of other races. There is evidence on the genetic determination and variability of the Apo (a) gene. The paper presents the results of the recent large survey of 8000 patients with coronary heart disease and 8000 control persons, which has studied candidate genes for cardiovascular diseases. It indicates the role of Lp (a) as a risk factor for early atherosclerosis and describes main pathomorphological mechanisms. The propositions that it is necessary to screen Lp (a) in different risk groups, its target level, and possible methods for correcting the elevated Lp (a) level are given. |
| first_indexed | 2024-04-10T02:03:11Z |
| format | Article |
| id | doaj.art-90a421198eef446da5afe7eef7a833b8 |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-04-10T02:03:11Z |
| publishDate | 2016-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-90a421198eef446da5afe7eef7a833b82023-03-13T08:42:15ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422016-03-0181909510.14412/2074-2711-2016-1-90-95544Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseasesN. A. Pizov0N. V. Pizova1Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia 5, Revolyutsionnaya St., Yaroslavl 150000Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia 5, Revolyutsionnaya St., Yaroslavl 150000The paper gives the data available in the literature on the role of a level of elevated lipoprotein (a) (Lp (a)) in the development of ischemic stroke and other cardiovascular diseases. It shows the normal level of Lp (a) and the typical distribution of its concentration for people of European origin and representatives of other races. There is evidence on the genetic determination and variability of the Apo (a) gene. The paper presents the results of the recent large survey of 8000 patients with coronary heart disease and 8000 control persons, which has studied candidate genes for cardiovascular diseases. It indicates the role of Lp (a) as a risk factor for early atherosclerosis and describes main pathomorphological mechanisms. The propositions that it is necessary to screen Lp (a) in different risk groups, its target level, and possible methods for correcting the elevated Lp (a) level are given.https://nnp.ima-press.net/nnp/article/view/589lipoprotein (a)ischemic strokecardiovascular diseasesatherosclerosis |
| spellingShingle | N. A. Pizov N. V. Pizova Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases Неврология, нейропсихиатрия, психосоматика lipoprotein (a) ischemic stroke cardiovascular diseases atherosclerosis |
| title | Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases |
| title_full | Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases |
| title_fullStr | Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases |
| title_full_unstemmed | Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases |
| title_short | Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases |
| title_sort | role of lipoprotein a in the development of ischemic stroke and other cardiovascular diseases |
| topic | lipoprotein (a) ischemic stroke cardiovascular diseases atherosclerosis |
| url | https://nnp.ima-press.net/nnp/article/view/589 |
| work_keys_str_mv | AT napizov roleoflipoproteinainthedevelopmentofischemicstrokeandothercardiovasculardiseases AT nvpizova roleoflipoproteinainthedevelopmentofischemicstrokeandothercardiovasculardiseases |