Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes
The etiology of Autism Spectrum Disorders (ASD) is a result of the interaction between genes and the environment. The study of epigenetic factors that affect gene expression, such as DNA methylation, has become an important area of research in ASD. In recent years, there has been an increasing body...
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MDPI AG
2023-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/10/1420 |
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| author | Mirna Edith Morales-Marín Xochitl Helga Castro Martínez Federico Centeno Cruz Francisco Barajas-Olmos Omar Náfate López Amalia Guadalupe Gómez Cotero Lorena Orozco Humberto Nicolini Sánchez |
| author_facet | Mirna Edith Morales-Marín Xochitl Helga Castro Martínez Federico Centeno Cruz Francisco Barajas-Olmos Omar Náfate López Amalia Guadalupe Gómez Cotero Lorena Orozco Humberto Nicolini Sánchez |
| author_sort | Mirna Edith Morales-Marín |
| collection | DOAJ |
| description | The etiology of Autism Spectrum Disorders (ASD) is a result of the interaction between genes and the environment. The study of epigenetic factors that affect gene expression, such as DNA methylation, has become an important area of research in ASD. In recent years, there has been an increasing body of evidence pointing to epigenetic mechanisms that influence brain development, as in the case of ASD, when gene methylation dysregulation is present. Our analysis revealed 853 differentially methylated CpG in ASD patients, affecting 509 genes across the genome. Enrichment analysis showed five related diseases, including autistic disorder and mental disorders, which are particularly significant. In this work, we identified 64 genes that were previously reported in the SFARI gene database, classified according to their impact index. Additionally, we identified new genes that have not been previously reported as candidates with differences in the methylation patterns of Mexican children with ASD. |
| first_indexed | 2024-03-10T21:23:40Z |
| format | Article |
| id | doaj.art-90a490f9c0304012a44790f05b59a676 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:40Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-90a490f9c0304012a44790f05b59a6762023-11-19T15:52:41ZengMDPI AGBrain Sciences2076-34252023-10-011310142010.3390/brainsci13101420Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate GenesMirna Edith Morales-Marín0Xochitl Helga Castro Martínez1Federico Centeno Cruz2Francisco Barajas-Olmos3Omar Náfate López4Amalia Guadalupe Gómez Cotero5Lorena Orozco6Humberto Nicolini Sánchez7Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoLaboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoLaboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoLaboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoHospital de Especialidades Pediátricas, Tuxtla Gutiérrez 29045, MexicoCentro de Investigación en Ciencias de la Salud, Unidad Santo Tomás, Instituto Politécnico Nacional, Mexico City 07738, MexicoLaboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoLaboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Mexico City 14610, MexicoThe etiology of Autism Spectrum Disorders (ASD) is a result of the interaction between genes and the environment. The study of epigenetic factors that affect gene expression, such as DNA methylation, has become an important area of research in ASD. In recent years, there has been an increasing body of evidence pointing to epigenetic mechanisms that influence brain development, as in the case of ASD, when gene methylation dysregulation is present. Our analysis revealed 853 differentially methylated CpG in ASD patients, affecting 509 genes across the genome. Enrichment analysis showed five related diseases, including autistic disorder and mental disorders, which are particularly significant. In this work, we identified 64 genes that were previously reported in the SFARI gene database, classified according to their impact index. Additionally, we identified new genes that have not been previously reported as candidates with differences in the methylation patterns of Mexican children with ASD.https://www.mdpi.com/2076-3425/13/10/1420ASDgene methylationMexican children |
| spellingShingle | Mirna Edith Morales-Marín Xochitl Helga Castro Martínez Federico Centeno Cruz Francisco Barajas-Olmos Omar Náfate López Amalia Guadalupe Gómez Cotero Lorena Orozco Humberto Nicolini Sánchez Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes Brain Sciences ASD gene methylation Mexican children |
| title | Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes |
| title_full | Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes |
| title_fullStr | Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes |
| title_full_unstemmed | Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes |
| title_short | Differential DNA Methylation from Autistic Children Enriches Evidence for Genes Associated with ASD and New Candidate Genes |
| title_sort | differential dna methylation from autistic children enriches evidence for genes associated with asd and new candidate genes |
| topic | ASD gene methylation Mexican children |
| url | https://www.mdpi.com/2076-3425/13/10/1420 |
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