The Non-Hemostatic Aspects of Transfused Platelets
Platelets transfusion is a safe process, but during or after the process, the recipient may experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this review, we focus on the inflammatory potential of platelet components (PCs) and their involvement in SARs. Recent evid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmed.2018.00042/full |
| _version_ | 1818155257574719488 |
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| author | Caroline Sut Caroline Sut Sofiane Tariket Sofiane Tariket Cécile Aubron Chaker Aloui Hind Hamzeh-Cognasse Philippe Berthelot Sandrine Laradi Sandrine Laradi Andreas Greinacher Olivier Garraud Olivier Garraud Fabrice Cognasse Fabrice Cognasse |
| author_facet | Caroline Sut Caroline Sut Sofiane Tariket Sofiane Tariket Cécile Aubron Chaker Aloui Hind Hamzeh-Cognasse Philippe Berthelot Sandrine Laradi Sandrine Laradi Andreas Greinacher Olivier Garraud Olivier Garraud Fabrice Cognasse Fabrice Cognasse |
| author_sort | Caroline Sut |
| collection | DOAJ |
| description | Platelets transfusion is a safe process, but during or after the process, the recipient may experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this review, we focus on the inflammatory potential of platelet components (PCs) and their involvement in SARs. Recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses. Blood platelets are involved in inflammation and various other aspects of innate immunity through the release of a plethora of immunomodulatory cytokines, chemokines, and associated molecules, collectively termed biological response modifiers that behave like ligands for endothelial and leukocyte receptors and for platelets themselves. The involvement of PCs in SARs—particularly on a critically ill patient’s context—could be related, at least in part, to the inflammatory functions of platelets, acquired during storage lesions. Moreover, we focus on causal link between platelet activation and immune-mediated disorders (transfusion-associated immunomodulation, platelets, polyanions, and bacterial defense and alloimmunization). This is linked to the platelets’ propensity to be activated even in the absence of deliberate stimuli and to the occurrence of time-dependent storage lesions. |
| first_indexed | 2024-12-11T14:39:32Z |
| format | Article |
| id | doaj.art-90a76f34fdb14ab4b0f7430bcfcea4ce |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T14:39:32Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-90a76f34fdb14ab4b0f7430bcfcea4ce2022-12-22T01:02:00ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-02-01510.3389/fmed.2018.00042337022The Non-Hemostatic Aspects of Transfused PlateletsCaroline Sut0Caroline Sut1Sofiane Tariket2Sofiane Tariket3Cécile Aubron4Chaker Aloui5Hind Hamzeh-Cognasse6Philippe Berthelot7Sandrine Laradi8Sandrine Laradi9Andreas Greinacher10Olivier Garraud11Olivier Garraud12Fabrice Cognasse13Fabrice Cognasse14GIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceEtablissement Français du Sang, Auvergne-Rhône-Alpes, Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceEtablissement Français du Sang, Auvergne-Rhône-Alpes, Saint-Etienne, FranceMédecine Intensive Réanimation, Centre Hospitalier Régionale et Universitaire de Brest, Université de Bretagne Occidentale, Brest, FranceGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceEtablissement Français du Sang, Auvergne-Rhône-Alpes, Saint-Etienne, FranceInstitute for Immunology and Transfusion Medicine, University of Greifswald, Greifswald, GermanyGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceInstitut National de Transfusion Sanguine (INTS), Paris, FranceGIMAP-EA3064, Université de Lyon, Saint-Étienne, FranceEtablissement Français du Sang, Auvergne-Rhône-Alpes, Saint-Etienne, FrancePlatelets transfusion is a safe process, but during or after the process, the recipient may experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this review, we focus on the inflammatory potential of platelet components (PCs) and their involvement in SARs. Recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses. Blood platelets are involved in inflammation and various other aspects of innate immunity through the release of a plethora of immunomodulatory cytokines, chemokines, and associated molecules, collectively termed biological response modifiers that behave like ligands for endothelial and leukocyte receptors and for platelets themselves. The involvement of PCs in SARs—particularly on a critically ill patient’s context—could be related, at least in part, to the inflammatory functions of platelets, acquired during storage lesions. Moreover, we focus on causal link between platelet activation and immune-mediated disorders (transfusion-associated immunomodulation, platelets, polyanions, and bacterial defense and alloimmunization). This is linked to the platelets’ propensity to be activated even in the absence of deliberate stimuli and to the occurrence of time-dependent storage lesions.http://journal.frontiersin.org/article/10.3389/fmed.2018.00042/fullplateletstransfusionCD40Lserious adverse reactioninflammationinnate immunity |
| spellingShingle | Caroline Sut Caroline Sut Sofiane Tariket Sofiane Tariket Cécile Aubron Chaker Aloui Hind Hamzeh-Cognasse Philippe Berthelot Sandrine Laradi Sandrine Laradi Andreas Greinacher Olivier Garraud Olivier Garraud Fabrice Cognasse Fabrice Cognasse The Non-Hemostatic Aspects of Transfused Platelets Frontiers in Medicine platelets transfusion CD40L serious adverse reaction inflammation innate immunity |
| title | The Non-Hemostatic Aspects of Transfused Platelets |
| title_full | The Non-Hemostatic Aspects of Transfused Platelets |
| title_fullStr | The Non-Hemostatic Aspects of Transfused Platelets |
| title_full_unstemmed | The Non-Hemostatic Aspects of Transfused Platelets |
| title_short | The Non-Hemostatic Aspects of Transfused Platelets |
| title_sort | non hemostatic aspects of transfused platelets |
| topic | platelets transfusion CD40L serious adverse reaction inflammation innate immunity |
| url | http://journal.frontiersin.org/article/10.3389/fmed.2018.00042/full |
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