Local Magnetic Hyperthermia and Systemic Gemcitabine/Paclitaxel Chemotherapy Triggers Neo-Angiogenesis in Orthotopic Pancreatic Tumors without Involvement of Auto/Paracrine Tumor Cell VEGF Signaling and Hypoxia

Local Magnetic Hyperthermia and Systemic Gemcitabine/Paclitaxel Chemotherapy Triggers Neo-Angiogenesis in Orthotopic Pancreatic Tumors without Involvement of Auto/Paracrine Tumor Cell VEGF Signaling and Hypoxia

There is a growing interest in exploring the therapeutically mediated modulation of tumor vascularization of pancreatic cancer, which is known for its poorly perfused tumor microenvironment limiting the delivery of therapeutic agents to the tumor site. Here, we assessed how magnetic hyperthermia in...

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Bibliographic Details
Main Authors: Wisdom O. Maduabuchi, Felista L. Tansi, Bernd Faenger, Paul Southern, Quentin A. Pankhurst, Frank Steiniger, Martin Westermann, Ingrid Hilger
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
pancreatic adenocarcinoma (PDAC)
angiogenesis
magnetic hyperthermia
chemotherapy
orthotopic tumor model
hypoxia
Online Access:https://www.mdpi.com/2072-6694/16/1/33

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