A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma
Abstract Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used as diagnostic and prognostic biomarkers and could be considered therapeutic targets in treating the same. Main body Studies have proven that miRNAs play an essential role in molecu...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2022-11-01
|
| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43042-022-00361-2 |
| _version_ | 1811329091415048192 |
|---|---|
| author | M. Kavitha D. Jayachandran S. Y. Aishwarya P. Md. Younus A. Venugopal H. W. Suresh Babu E. Ajay M. Sanjana N. Arul V. Balachandar |
| author_facet | M. Kavitha D. Jayachandran S. Y. Aishwarya P. Md. Younus A. Venugopal H. W. Suresh Babu E. Ajay M. Sanjana N. Arul V. Balachandar |
| author_sort | M. Kavitha |
| collection | DOAJ |
| description | Abstract Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used as diagnostic and prognostic biomarkers and could be considered therapeutic targets in treating the same. Main body Studies have proven that miRNAs play an essential role in molecular cancer pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different miRNAs have been demonstrated in oral squamous cell carcinoma. Among the miRNAs, the miR-31 has strong potential as a unique biomarker in head and neck squamous cell carcinoma, and the increased expression was correlated to a poor clinical outcome with a likely contribution to oral carcinogenesis. Short conclusion The recent research on different aspects of miR-31 as a biomarker and also its potential application in the development of therapy for oral squamous cell carcinoma has been focused in this review. Graphical abstract |
| first_indexed | 2024-04-13T15:37:45Z |
| format | Article |
| id | doaj.art-90a97efc0cc541ae9ffa6a9c0fdcd135 |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-04-13T15:37:45Z |
| publishDate | 2022-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-90a97efc0cc541ae9ffa6a9c0fdcd1352022-12-22T02:41:13ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412022-11-0123111010.1186/s43042-022-00361-2A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinomaM. Kavitha0D. Jayachandran1S. Y. Aishwarya2P. Md. Younus3A. Venugopal4H. W. Suresh Babu5E. Ajay6M. Sanjana7N. Arul8V. Balachandar9Department of Oral Medicine and Radiology, VMS Dental College, Vinayaka Mission’s Research Foundation Deemed to be UniversityDepartment of Periodontology, VMS Dental College, Vinayaka Mission’s Research Foundation Deemed to Be UniversityDepartment of Biotechnology, Sri Shakthi Institute of Engineering and TechnologyHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversityHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversityDisease Proteomics Laboratory, Department of Zoology, Bharathiar UniversityHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversityHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversityDisease Proteomics Laboratory, Department of Zoology, Bharathiar UniversityHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversityAbstract Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used as diagnostic and prognostic biomarkers and could be considered therapeutic targets in treating the same. Main body Studies have proven that miRNAs play an essential role in molecular cancer pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different miRNAs have been demonstrated in oral squamous cell carcinoma. Among the miRNAs, the miR-31 has strong potential as a unique biomarker in head and neck squamous cell carcinoma, and the increased expression was correlated to a poor clinical outcome with a likely contribution to oral carcinogenesis. Short conclusion The recent research on different aspects of miR-31 as a biomarker and also its potential application in the development of therapy for oral squamous cell carcinoma has been focused in this review. Graphical abstracthttps://doi.org/10.1186/s43042-022-00361-2miRNAsOral cancerHead and Neck Squamous Cell CarcinomamiR-31Biomarker |
| spellingShingle | M. Kavitha D. Jayachandran S. Y. Aishwarya P. Md. Younus A. Venugopal H. W. Suresh Babu E. Ajay M. Sanjana N. Arul V. Balachandar A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma Egyptian Journal of Medical Human Genetics miRNAs Oral cancer Head and Neck Squamous Cell Carcinoma miR-31 Biomarker |
| title | A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma |
| title_full | A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma |
| title_fullStr | A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma |
| title_full_unstemmed | A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma |
| title_short | A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma |
| title_sort | new insight into the diverse facets of microrna 31 in oral squamous cell carcinoma |
| topic | miRNAs Oral cancer Head and Neck Squamous Cell Carcinoma miR-31 Biomarker |
| url | https://doi.org/10.1186/s43042-022-00361-2 |
| work_keys_str_mv | AT mkavitha anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT djayachandran anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT syaishwarya anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT pmdyounus anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT avenugopal anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT hwsureshbabu anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT eajay anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT msanjana anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT narul anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT vbalachandar anewinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT mkavitha newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT djayachandran newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT syaishwarya newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT pmdyounus newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT avenugopal newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT hwsureshbabu newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT eajay newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT msanjana newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT narul newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma AT vbalachandar newinsightintothediversefacetsofmicrorna31inoralsquamouscellcarcinoma |