Mucin-Type O-Glycosylation in Invertebrates
O-Glycosylation is one of the most important posttranslational modifications of proteins. It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well u...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/20/6/10622 |
| _version_ | 1828523751814201344 |
|---|---|
| author | Erika Staudacher |
| author_facet | Erika Staudacher |
| author_sort | Erika Staudacher |
| collection | DOAJ |
| description | O-Glycosylation is one of the most important posttranslational modifications of proteins. It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well understood. However, the regulation of the processes and the molecular aspects of defects, especially in correlation with cancer or developmental abnormalities, are still under investigation. The knowledge of the correlating invertebrate systems and evolutionary aspects of these highly conserved biosynthetic events may help improve the understanding of the regulatory factors of this pathway. Invertebrates display a broad spectrum of glycosylation varieties, providing an enormous potential for glycan modifications which may be used for the design of new pharmaceutically active substances. Here, overviews of the present knowledge of invertebrate mucin-type O-glycan structures and the currently identified enzymes responsible for the biosynthesis of these oligosaccharides are presented, and the few data dealing with functional aspects of O-glycans are summarised. |
| first_indexed | 2024-12-11T20:33:31Z |
| format | Article |
| id | doaj.art-90aa7bd3f72f4cb1a6bfffd41fdf45d8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T20:33:31Z |
| publishDate | 2015-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-90aa7bd3f72f4cb1a6bfffd41fdf45d82022-12-22T00:51:44ZengMDPI AGMolecules1420-30492015-06-01206106221064010.3390/molecules200610622molecules200610622Mucin-Type O-Glycosylation in InvertebratesErika Staudacher0Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, AustriaO-Glycosylation is one of the most important posttranslational modifications of proteins. It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well understood. However, the regulation of the processes and the molecular aspects of defects, especially in correlation with cancer or developmental abnormalities, are still under investigation. The knowledge of the correlating invertebrate systems and evolutionary aspects of these highly conserved biosynthetic events may help improve the understanding of the regulatory factors of this pathway. Invertebrates display a broad spectrum of glycosylation varieties, providing an enormous potential for glycan modifications which may be used for the design of new pharmaceutically active substances. Here, overviews of the present knowledge of invertebrate mucin-type O-glycan structures and the currently identified enzymes responsible for the biosynthesis of these oligosaccharides are presented, and the few data dealing with functional aspects of O-glycans are summarised.http://www.mdpi.com/1420-3049/20/6/10622O-glycosylationinvertebratesmucin-typenematodeinsecthelminthmollusc |
| spellingShingle | Erika Staudacher Mucin-Type O-Glycosylation in Invertebrates Molecules O-glycosylation invertebrates mucin-type nematode insect helminth mollusc |
| title | Mucin-Type O-Glycosylation in Invertebrates |
| title_full | Mucin-Type O-Glycosylation in Invertebrates |
| title_fullStr | Mucin-Type O-Glycosylation in Invertebrates |
| title_full_unstemmed | Mucin-Type O-Glycosylation in Invertebrates |
| title_short | Mucin-Type O-Glycosylation in Invertebrates |
| title_sort | mucin type o glycosylation in invertebrates |
| topic | O-glycosylation invertebrates mucin-type nematode insect helminth mollusc |
| url | http://www.mdpi.com/1420-3049/20/6/10622 |
| work_keys_str_mv | AT erikastaudacher mucintypeoglycosylationininvertebrates |