Shifts in myeloarchitecture characterise adolescent development of cortical gradients
We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/50482 |
| _version_ | 1811227555136536576 |
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| author | Casey Paquola Richard AI Bethlehem Jakob Seidlitz Konrad Wagstyl Rafael Romero-Garcia Kirstie J Whitaker Reinder Vos de Wael Guy B Williams NSPN Consortium Petra E Vértes Daniel S Margulies Boris Bernhardt Edward T Bullmore |
| author_facet | Casey Paquola Richard AI Bethlehem Jakob Seidlitz Konrad Wagstyl Rafael Romero-Garcia Kirstie J Whitaker Reinder Vos de Wael Guy B Williams NSPN Consortium Petra E Vértes Daniel S Margulies Boris Bernhardt Edward T Bullmore |
| author_sort | Casey Paquola |
| collection | DOAJ |
| description | We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation. |
| first_indexed | 2024-04-12T09:44:31Z |
| format | Article |
| id | doaj.art-90ab47671c3b4f969f46dcccd1decbd8 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:44:31Z |
| publishDate | 2019-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-90ab47671c3b4f969f46dcccd1decbd82022-12-22T03:37:59ZengeLife Sciences Publications LtdeLife2050-084X2019-11-01810.7554/eLife.50482Shifts in myeloarchitecture characterise adolescent development of cortical gradientsCasey Paquola0https://orcid.org/0000-0002-0190-4103Richard AI Bethlehem1https://orcid.org/0000-0002-0714-0685Jakob Seidlitz2https://orcid.org/0000-0002-8164-7476Konrad Wagstyl3Rafael Romero-Garcia4Kirstie J Whitaker5Reinder Vos de Wael6Guy B Williams7NSPN ConsortiumPetra E Vértes8https://orcid.org/0000-0002-0992-3210Daniel S Margulies9Boris Bernhardt10https://orcid.org/0000-0001-9256-6041Edward T Bullmore11Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, CanadaDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, United StatesDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; The Alan Turing Institute, London, United KingdomMultimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, CanadaDepartment of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; The Alan Turing Institute, London, United KingdomFrontlab, Institut du Cerveau et de la Moelle épinière, UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, FranceMultimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, CanadaDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United KingdomWe studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation.https://elifesciences.org/articles/50482adolescenceMRImicrostructurehierarchygradientstranscriptomics |
| spellingShingle | Casey Paquola Richard AI Bethlehem Jakob Seidlitz Konrad Wagstyl Rafael Romero-Garcia Kirstie J Whitaker Reinder Vos de Wael Guy B Williams NSPN Consortium Petra E Vértes Daniel S Margulies Boris Bernhardt Edward T Bullmore Shifts in myeloarchitecture characterise adolescent development of cortical gradients eLife adolescence MRI microstructure hierarchy gradients transcriptomics |
| title | Shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| title_full | Shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| title_fullStr | Shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| title_full_unstemmed | Shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| title_short | Shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| title_sort | shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| topic | adolescence MRI microstructure hierarchy gradients transcriptomics |
| url | https://elifesciences.org/articles/50482 |
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