Unnatural Amino Acid‐Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice

Unnatural Amino Acid‐Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice

Abstract This investigation addresses the challenge of suboptimal unnatural amino acid (UAA) utilization in the site‐specific suppression of nonsense mutations through genetic code expansion, which is crucial for protein restoration and precise property tailoring. A facile and economical oral liquid...

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Bibliographic Details
Main Authors: Yujie Shi, Ningning Shi, Yuelin Yang, Zhetao Zheng, Qing Xia
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
ionic liquid
DMD
dystrophin restoration
oral treatment
unnatural amino acid
Online Access:https://doi.org/10.1002/advs.202306792

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