Oral Treatment of Spontaneously Hypertensive Rats with Captopril-Surface Functionalized Furosemide-Loaded Multi-Wall Lipid-Core Nanocapsules

Oral Treatment of Spontaneously Hypertensive Rats with Captopril-Surface Functionalized Furosemide-Loaded Multi-Wall Lipid-Core Nanocapsules

Multi-wall lipid-core nanocapsule (MLNC) functionalized with captopril and nanoencapsulating furosemide within the core was developed as a liquid formulation for oral administration. The nanocapsules had mean particle size below 200 nm, showing unimodal and narrow size distributions with moderate di...

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Bibliographic Details
Main Authors: Cecilia B. Michalowski, Marcelo D. Arbo, Louise Altknecht, Andréia N. Anciuti, Angélica S. G. Abreu, Luciana M. R. Alencar, Adriana R. Pohlmann, Solange C. Garcia, Sílvia S. Guterres
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
lipid-core nanocapsules
antihypertensive
surface-functionalization
captopril
furosemide
toxicity
oral drug delivery
Online Access:https://www.mdpi.com/1999-4923/12/1/80

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