Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: <i>N</i>-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: <i>N</i>-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile

Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-<i>N</i>-acyl-alkylene (<b>3</b>) and bis-<i>N</i>-thiourea...

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Bibliographic Details
Main Authors: Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
amiridine
<i>N</i>-acylamide
thiourea
acetylcholinesterase (AChE)
butyrylcholinesterase (BChE)
antioxidants
Online Access:https://www.mdpi.com/1420-3049/27/3/1060

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https://www.mdpi.com/1420-3049/27/3/1060

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