NOD-like receptors in lung diseases
The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00393/full |
| _version_ | 1811318809905070080 |
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| author | Catherine eChaput Leif Erik Sander Norbert eSuttorp Bastian eOpitz |
| author_facet | Catherine eChaput Leif Erik Sander Norbert eSuttorp Bastian eOpitz |
| author_sort | Catherine eChaput |
| collection | DOAJ |
| description | The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avoiding extensive tissue damage. NOD-like receptors (NLRs) represent a group of key sensors for microbes and damage in the lung. As such they are important players in various infectious as well as acute and chronic sterile inflammatory diseases, such as pneumonia, chronic obstructive lung disease (COPD), acute lung injury/ARDS, pneumoconiosis and asthma. Activation of most known NLRs leads to the production and release of pro-inflammatory cytokines, and/or to the induction of cell death. We will review NLR functions in the lung during infection and sterile inflammation. |
| first_indexed | 2024-04-13T12:30:47Z |
| format | Article |
| id | doaj.art-90b10c9c40dc462e890c6885d0fd72a2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T12:30:47Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-90b10c9c40dc462e890c6885d0fd72a22022-12-22T02:46:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-11-01410.3389/fimmu.2013.0039365101NOD-like receptors in lung diseasesCatherine eChaput0Leif Erik Sander1Norbert eSuttorp2Bastian eOpitz3Charité Universitätsmedizin BerlinCharité Universitätsmedizin BerlinCharité Universitätsmedizin BerlinCharité Universitätsmedizin BerlinThe lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avoiding extensive tissue damage. NOD-like receptors (NLRs) represent a group of key sensors for microbes and damage in the lung. As such they are important players in various infectious as well as acute and chronic sterile inflammatory diseases, such as pneumonia, chronic obstructive lung disease (COPD), acute lung injury/ARDS, pneumoconiosis and asthma. Activation of most known NLRs leads to the production and release of pro-inflammatory cytokines, and/or to the induction of cell death. We will review NLR functions in the lung during infection and sterile inflammation.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00393/fullLungLung InjuryPneumoniaInflammasomenod-like receptors |
| spellingShingle | Catherine eChaput Leif Erik Sander Norbert eSuttorp Bastian eOpitz NOD-like receptors in lung diseases Frontiers in Immunology Lung Lung Injury Pneumonia Inflammasome nod-like receptors |
| title | NOD-like receptors in lung diseases |
| title_full | NOD-like receptors in lung diseases |
| title_fullStr | NOD-like receptors in lung diseases |
| title_full_unstemmed | NOD-like receptors in lung diseases |
| title_short | NOD-like receptors in lung diseases |
| title_sort | nod like receptors in lung diseases |
| topic | Lung Lung Injury Pneumonia Inflammasome nod-like receptors |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00393/full |
| work_keys_str_mv | AT catherineechaput nodlikereceptorsinlungdiseases AT leiferiksander nodlikereceptorsinlungdiseases AT norbertesuttorp nodlikereceptorsinlungdiseases AT bastianeopitz nodlikereceptorsinlungdiseases |