Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection
Junctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development. These include processes such as inflammation, angiogenesis, hemostasis, or epithe...
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MDPI AG
2018-03-01
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Online Access: | http://www.mdpi.com/2073-4409/7/4/25 |
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author | Daniel Kummer Klaus Ebnet |
author_facet | Daniel Kummer Klaus Ebnet |
author_sort | Daniel Kummer |
collection | DOAJ |
description | Junctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development. These include processes such as inflammation, angiogenesis, hemostasis, or epithelial barrier formation, but also developmental processes such as hematopoiesis, germ cell development, and development of the nervous system. Several of these functions of JAMs depend on a physical and functional interaction with integrins. The JAM – integrin interactions in trans regulate cell-cell adhesion, their interactions in cis regulate signaling processes originating at the cell surface. The JAM – integrin interaction can regulate the function of the JAM as well as the function of the integrin. Beyond the physical interaction with integrins, JAMs can regulate integrin function through intracellular signaling indicating an additional level of JAM – integrin cross-talk. In this review, we describe the various levels of the functional interplay between JAMs and integrins and the role of this interplay during different physiological processes. |
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language | English |
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spelling | doaj.art-90b12378254f4f7ba313deeb9fe52d9b2023-08-02T03:52:28ZengMDPI AGCells2073-44092018-03-01742510.3390/cells7040025cells7040025Junctional Adhesion Molecules (JAMs): The JAM-Integrin ConnectionDaniel Kummer0Klaus Ebnet1Institute-Associated Research Group: Cell Adhesion and Cell Polarity, Institute of Medical Biochemistry, ZMBE, University of Münster, Von-Esmarch-Str. 56, D-48149 Münster, GermanyInstitute-Associated Research Group: Cell Adhesion and Cell Polarity, Institute of Medical Biochemistry, ZMBE, University of Münster, Von-Esmarch-Str. 56, D-48149 Münster, GermanyJunctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development. These include processes such as inflammation, angiogenesis, hemostasis, or epithelial barrier formation, but also developmental processes such as hematopoiesis, germ cell development, and development of the nervous system. Several of these functions of JAMs depend on a physical and functional interaction with integrins. The JAM – integrin interactions in trans regulate cell-cell adhesion, their interactions in cis regulate signaling processes originating at the cell surface. The JAM – integrin interaction can regulate the function of the JAM as well as the function of the integrin. Beyond the physical interaction with integrins, JAMs can regulate integrin function through intracellular signaling indicating an additional level of JAM – integrin cross-talk. In this review, we describe the various levels of the functional interplay between JAMs and integrins and the role of this interplay during different physiological processes.http://www.mdpi.com/2073-4409/7/4/25cis-interactionintegrinjunctional adhesion molecule (JAM)JAM-Atrans-interactionleukocyte adhesionsignaling complextetraspanintetraspanin-enriched microdomain |
spellingShingle | Daniel Kummer Klaus Ebnet Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection Cells cis-interaction integrin junctional adhesion molecule (JAM) JAM-A trans-interaction leukocyte adhesion signaling complex tetraspanin tetraspanin-enriched microdomain |
title | Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection |
title_full | Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection |
title_fullStr | Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection |
title_full_unstemmed | Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection |
title_short | Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection |
title_sort | junctional adhesion molecules jams the jam integrin connection |
topic | cis-interaction integrin junctional adhesion molecule (JAM) JAM-A trans-interaction leukocyte adhesion signaling complex tetraspanin tetraspanin-enriched microdomain |
url | http://www.mdpi.com/2073-4409/7/4/25 |
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