Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor
Serotonin is a very important monoamine neurotransmitter, which takes part in biological and psychological processes. In the present scenario, design and fabrication of a serotonin electrochemical sensor is of great significance. In this study, we have synthesized α-MnO<sub>2</sub> via a...
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MDPI AG
2022-10-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/10/849 |
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| author | Mohd Quasim Khan Rais Ahmad Khan Ali Alsalme Khursheed Ahmad Haekyoung Kim |
| author_facet | Mohd Quasim Khan Rais Ahmad Khan Ali Alsalme Khursheed Ahmad Haekyoung Kim |
| author_sort | Mohd Quasim Khan |
| collection | DOAJ |
| description | Serotonin is a very important monoamine neurotransmitter, which takes part in biological and psychological processes. In the present scenario, design and fabrication of a serotonin electrochemical sensor is of great significance. In this study, we have synthesized α-MnO<sub>2</sub> via a hydrothermal synthesis method using potassium permanganate as a precursor. The physiochemical properties, such as structural and phase-purity of the prepared α-MnO<sub>2</sub>, were investigated by various characterization techniques and methods (powder X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy). Furthermore, the serotonin sensor was fabricated using α-MnO<sub>2</sub> as an electrode modifier or electro-catalyst. The bare glassy carbon electrode (GCE) was adopted as a working substrate, and its active carbon surface was modified with the synthesized α-MnO<sub>2</sub>. This modified GCE (<b>α-MnO<sub>2</sub>/GCE = MGCE</b>) was explored as a serotonin sensor. The electrochemical investigations showed that the <b>MGCE</b> has excellent electro-catalytic properties towards determination of serotonin. The <b>MGCE</b> exhibits an excellent detection limit (DL) of 0.14 µM, along with good sensitivity of 2.41 µAµM<sup>−1</sup> cm<sup>−2</sup>. The <b>MGCE</b> also demonstrated excellent selectivity for determination of serotonin in the presence of various electro-active/interfering molecules. The <b>MGCE</b> also exhibits good cyclic repeatability, stability, and storage stability. |
| first_indexed | 2024-03-09T20:36:06Z |
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| id | doaj.art-90b3f12fe1f345488937ee4637c2afcc |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T20:36:06Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-90b3f12fe1f345488937ee4637c2afcc2023-11-23T23:11:40ZengMDPI AGBiosensors2079-63742022-10-01121084910.3390/bios12100849Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin SensorMohd Quasim Khan0Rais Ahmad Khan1Ali Alsalme2Khursheed Ahmad3Haekyoung Kim4Department of Chemistry, M.M.D. College, Moradabad, M.J.P. Rohilkhand University, Bareilly 244001, UP, IndiaDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaSchool of Materials Science and Engineering, Yeungnam University, Gyeongsan 38541, KoreaSchool of Materials Science and Engineering, Yeungnam University, Gyeongsan 38541, KoreaSerotonin is a very important monoamine neurotransmitter, which takes part in biological and psychological processes. In the present scenario, design and fabrication of a serotonin electrochemical sensor is of great significance. In this study, we have synthesized α-MnO<sub>2</sub> via a hydrothermal synthesis method using potassium permanganate as a precursor. The physiochemical properties, such as structural and phase-purity of the prepared α-MnO<sub>2</sub>, were investigated by various characterization techniques and methods (powder X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy). Furthermore, the serotonin sensor was fabricated using α-MnO<sub>2</sub> as an electrode modifier or electro-catalyst. The bare glassy carbon electrode (GCE) was adopted as a working substrate, and its active carbon surface was modified with the synthesized α-MnO<sub>2</sub>. This modified GCE (<b>α-MnO<sub>2</sub>/GCE = MGCE</b>) was explored as a serotonin sensor. The electrochemical investigations showed that the <b>MGCE</b> has excellent electro-catalytic properties towards determination of serotonin. The <b>MGCE</b> exhibits an excellent detection limit (DL) of 0.14 µM, along with good sensitivity of 2.41 µAµM<sup>−1</sup> cm<sup>−2</sup>. The <b>MGCE</b> also demonstrated excellent selectivity for determination of serotonin in the presence of various electro-active/interfering molecules. The <b>MGCE</b> also exhibits good cyclic repeatability, stability, and storage stability.https://www.mdpi.com/2079-6374/12/10/849α-MnO<sub>2</sub>/GCEserotoninsensorelectrochemistry |
| spellingShingle | Mohd Quasim Khan Rais Ahmad Khan Ali Alsalme Khursheed Ahmad Haekyoung Kim Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor Biosensors α-MnO<sub>2</sub>/GCE serotonin sensor electrochemistry |
| title | Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor |
| title_full | Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor |
| title_fullStr | Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor |
| title_full_unstemmed | Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor |
| title_short | Design and Fabrication of α-MnO<sub>2</sub>-Nanorods-Modified Glassy-Carbon-Electrode-Based Serotonin Sensor |
| title_sort | design and fabrication of α mno sub 2 sub nanorods modified glassy carbon electrode based serotonin sensor |
| topic | α-MnO<sub>2</sub>/GCE serotonin sensor electrochemistry |
| url | https://www.mdpi.com/2079-6374/12/10/849 |
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