Transglutaminase inhibition: possible therapeutic mechanisms to protect cells from death in neurological disorders

Transglutaminase inhibition: possible therapeutic mechanisms to protect cells from death in neurological disorders

Transglutaminases are a family of Ca<sup>2+</sup>-dependent enzymes which catalyze post-translational modifications of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/peptide substrate to lysyl residues of a protein/peptide co-substra...

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Bibliographic Details
Main Authors: Nicola Gaetano Gatta, Rosaria Romano, Elenamaria Fioretti, Vittorio Gentile
Format: Article
Language:English
Published: AIMS Press 2017-10-01
Series:AIMS Molecular Science
Subjects:
transglutaminases
post-translational modifications of proteins
neurodegeneration
NF-kB
neuroinflammation
Online Access:http://www.aimspress.com/Molecular/article/1636/fulltext.html

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