Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81 (opicinumab), which blocks LINGO-1 function a...

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Bibliographic Details
Main Authors: Karl J. M. Hanf, Joseph W. Arndt, YuTing Liu, Bang Jian Gong, Mia Rushe, Richelle Sopko, Ramiro Massol, Benjamin Smith, Yan Gao, Isin Dalkilic-Liddle, Xinhua Lee, Shanell Mojta, Zhaohui Shao, Sha Mi, R. Blake Pepinsky
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
LINGO-1
anti-LINGO-1 antibody
opicinumab
multiple sclerosis
oligodendrocyte
remyelination
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1713648

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