Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques
Aphasia is a common complication of stroke, often causing significant morbidity. To the authors' knowledge, no stroke recovery practice guidelines incorporating pharmacologic or noninvasive brain stimulation (NIBS) therapies for poststroke aphasia (PSA) exist. The aim of this article is to prov...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2022-01-01
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| Series: | The Journal of the International Society of Physical and Rehabilitation Medicine |
| Subjects: | |
| Online Access: | http://www.jisprm.org/article.asp?issn=2349-7904;year=2022;volume=5;issue=1;spage=1;epage=15;aulast=Capizzi |
| _version_ | 1827332720238264320 |
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| author | Allison Nuovo Capizzi Jean E Woo Elaine Magat |
| author_facet | Allison Nuovo Capizzi Jean E Woo Elaine Magat |
| author_sort | Allison Nuovo Capizzi |
| collection | DOAJ |
| description | Aphasia is a common complication of stroke, often causing significant morbidity. To the authors' knowledge, no stroke recovery practice guidelines incorporating pharmacologic or noninvasive brain stimulation (NIBS) therapies for poststroke aphasia (PSA) exist. The aim of this article is to provide a comprehensive review of the evidence regarding pharmacologic and NIBS treatment in PSA. An exhaustive single database search assessing treatment for PSA was performed from 2010 to 2020, resulting in 1876 articles. Articles evaluating either pharmacologic management or NIBS were included. Case reports, case series, original research, systematic reviews, and meta-analyses were allowed. Pharmacologic treatment studies included were represented by the following medication classes: cholinergic, dopaminergic, gamma-aminobutyric acid agonists and derivatives, N-methyl-D-aspartate receptor antagonists, serotonergic, and autonomic agents. NIBS treatment studies regarding transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) were evaluated. No strong evidence was found for any medication to improve PSA. However, the benefit of a medication trial may outweigh the risk of side effects as some evidence exists for functional recovery. Regarding NIBS, weak evidence exists for the treatment effect of tDCS and rTMS on PSA. While additional research is needed, the literature shows promise, especially in chronic phase of stroke when traditional treatment options may be exhausted. More evidence with larger studies and standardized study design is needed. |
| first_indexed | 2024-03-07T17:04:59Z |
| format | Article |
| id | doaj.art-90b4ea6d038b43c0be52d46f54180a8c |
| institution | Directory Open Access Journal |
| issn | 2589-9457 |
| language | English |
| last_indexed | 2024-03-07T17:04:59Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | The Journal of the International Society of Physical and Rehabilitation Medicine |
| spelling | doaj.art-90b4ea6d038b43c0be52d46f54180a8c2024-03-03T02:48:02ZengWolters Kluwer Health - Lippincott Williams WilkinsThe Journal of the International Society of Physical and Rehabilitation Medicine2589-94572022-01-015111510.4103/jisprm.JISPRM-000151Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniquesAllison Nuovo CapizziJean E WooElaine MagatAphasia is a common complication of stroke, often causing significant morbidity. To the authors' knowledge, no stroke recovery practice guidelines incorporating pharmacologic or noninvasive brain stimulation (NIBS) therapies for poststroke aphasia (PSA) exist. The aim of this article is to provide a comprehensive review of the evidence regarding pharmacologic and NIBS treatment in PSA. An exhaustive single database search assessing treatment for PSA was performed from 2010 to 2020, resulting in 1876 articles. Articles evaluating either pharmacologic management or NIBS were included. Case reports, case series, original research, systematic reviews, and meta-analyses were allowed. Pharmacologic treatment studies included were represented by the following medication classes: cholinergic, dopaminergic, gamma-aminobutyric acid agonists and derivatives, N-methyl-D-aspartate receptor antagonists, serotonergic, and autonomic agents. NIBS treatment studies regarding transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) were evaluated. No strong evidence was found for any medication to improve PSA. However, the benefit of a medication trial may outweigh the risk of side effects as some evidence exists for functional recovery. Regarding NIBS, weak evidence exists for the treatment effect of tDCS and rTMS on PSA. While additional research is needed, the literature shows promise, especially in chronic phase of stroke when traditional treatment options may be exhausted. More evidence with larger studies and standardized study design is needed.http://www.jisprm.org/article.asp?issn=2349-7904;year=2022;volume=5;issue=1;spage=1;epage=15;aulast=Capizziaphasiastroke rehabilitationtranscranial direct current stimulationtranscranial magnetic stimulation |
| spellingShingle | Allison Nuovo Capizzi Jean E Woo Elaine Magat Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques The Journal of the International Society of Physical and Rehabilitation Medicine aphasia stroke rehabilitation transcranial direct current stimulation transcranial magnetic stimulation |
| title | Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques |
| title_full | Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques |
| title_fullStr | Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques |
| title_full_unstemmed | Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques |
| title_short | Poststroke aphasia treatment: A review of pharmacologic therapies and noninvasive brain stimulation techniques |
| title_sort | poststroke aphasia treatment a review of pharmacologic therapies and noninvasive brain stimulation techniques |
| topic | aphasia stroke rehabilitation transcranial direct current stimulation transcranial magnetic stimulation |
| url | http://www.jisprm.org/article.asp?issn=2349-7904;year=2022;volume=5;issue=1;spage=1;epage=15;aulast=Capizzi |
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