Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series
The fundic gland type (GA-FG) of gastric adenocarcinoma is a rare variant of gastric cancer recently included in the 5th edition of the World Health Organization’s classification of digestive system tumors. Five patients with GA-FG underwent an endoscopic resection at our institution. None of the pa...
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2023-06-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5927&vmd=Full |
| _version_ | 1827319073149550592 |
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| author | Hwa Jin Lee Gwang Ha Kim Dong Chan Joo Moon Won Lee Bong Eun Lee Kyungbin Kim |
| author_facet | Hwa Jin Lee Gwang Ha Kim Dong Chan Joo Moon Won Lee Bong Eun Lee Kyungbin Kim |
| author_sort | Hwa Jin Lee |
| collection | DOAJ |
| description | The fundic gland type (GA-FG) of gastric adenocarcinoma is a rare variant of gastric cancer recently included in the 5th edition of the World Health Organization’s classification of digestive system tumors. Five patients with GA-FG underwent an endoscopic resection at our institution. None of the patients had a Helicobacter pylori infection. Four lesions were located in the upper third of the stomach, and one was in the lower third. Three lesions had a IIa shape, while two resembled a subepithelial tumor. An endoscopic submucosal dissection was performed in four patients and endoscopic mucosal resection in one. Tumor cells were composed of well-differentiated columnar cells mimicking fundic gland cells, and the median tumor size was 10 mm. Three lesions exhibited submucosal invasion. No lymphatic or venous invasion was observed. Tumor cells were positive for MUC6 in all five cases; one case was focally positive for MUC5AC. No recurrence was observed during a median follow-up period of 13 months. An endoscopic resection can be a safe treatment modality for GA-FG, considering its small size and low risk of recurrence or metastasis. |
| first_indexed | 2024-04-25T00:13:35Z |
| format | Article |
| id | doaj.art-90b845efb83343c7824962679464e440 |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-04-25T00:13:35Z |
| publishDate | 2023-06-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-90b845efb83343c7824962679464e4402024-03-13T07:14:47ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692023-06-0181625926410.4166/kjg.2023.019Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case SeriesHwa Jin Lee0Gwang Ha Kim1https://orcid.org/0000-0001-9721-5734Dong Chan Joo2Moon Won Lee3Bong Eun Lee4Kyungbin Kim5Division of Gastroenterology, Pusan National University Hospital, Busan, KoreaDivision of Gastroenterology, Pusan National University Hospital; Department of Internal Medicine, Pusan National University School of Medicine; Biomedical Research Institute, Pusan National University Hospital, Busan, KoreaDivision of Gastroenterology, Pusan National University Hospital, Busan, KoreaDivision of Gastroenterology, Pusan National University Hospital; Department of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDivision of Gastroenterology, Pusan National University Hospital; Department of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Pathology, Pusan National University Hospital, Busan, KoreaThe fundic gland type (GA-FG) of gastric adenocarcinoma is a rare variant of gastric cancer recently included in the 5th edition of the World Health Organization’s classification of digestive system tumors. Five patients with GA-FG underwent an endoscopic resection at our institution. None of the patients had a Helicobacter pylori infection. Four lesions were located in the upper third of the stomach, and one was in the lower third. Three lesions had a IIa shape, while two resembled a subepithelial tumor. An endoscopic submucosal dissection was performed in four patients and endoscopic mucosal resection in one. Tumor cells were composed of well-differentiated columnar cells mimicking fundic gland cells, and the median tumor size was 10 mm. Three lesions exhibited submucosal invasion. No lymphatic or venous invasion was observed. Tumor cells were positive for MUC6 in all five cases; one case was focally positive for MUC5AC. No recurrence was observed during a median follow-up period of 13 months. An endoscopic resection can be a safe treatment modality for GA-FG, considering its small size and low risk of recurrence or metastasis.https://www.kjg.or.kr/journal/view.html?uid=5927&vmd=Fullchief cellsgastricgastric cancerendoscopic submucosal dissection |
| spellingShingle | Hwa Jin Lee Gwang Ha Kim Dong Chan Joo Moon Won Lee Bong Eun Lee Kyungbin Kim Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series The Korean Journal of Gastroenterology chief cells gastric gastric cancer endoscopic submucosal dissection |
| title | Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series |
| title_full | Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series |
| title_fullStr | Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series |
| title_full_unstemmed | Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series |
| title_short | Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series |
| title_sort | endoscopic resection for gastric adenocarcinoma of the fundic gland type a case series |
| topic | chief cells gastric gastric cancer endoscopic submucosal dissection |
| url | https://www.kjg.or.kr/journal/view.html?uid=5927&vmd=Full |
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