BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice

BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice

Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor <i>endoglin</i>. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1 patients display an impaired im...

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Bibliographic Details
Main Authors: Wineke Bakker, Calinda K. E. Dingenouts, Kirsten Lodder, Karien C. Wiesmeijer, Alwin de Jong, Kondababu Kurakula, Hans-Jurgen J. Mager, Anke M. Smits, Margreet R. de Vries, Paul H. A. Quax, Marie José T. H. Goumans
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
transforming growth factor-β
endoglin
neovascularization
tissue repair
myocardial infarction
hind limb ischemia
Online Access:https://www.mdpi.com/1422-0067/22/4/2010

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