Current understanding of epigenetics role in melanoma treatment and resistance
Abstract Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes in mechanisms of cell growth and proli...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02738-0 |
| _version_ | 1811238859780915200 |
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| author | Mohsen Karami Fath Ali Azargoonjahromi Asma Soofi Faezeh Almasi Shahnaz Hosseinzadeh Saeed Khalili Kamran Sheikhi Saeid Ferdousmakan Soroor Owrangi Minoovash Fahimi Hamidreza Zalpoor Mohsen Nabi Afjadi Zahra Payandeh Navid Pourzardosht |
| author_facet | Mohsen Karami Fath Ali Azargoonjahromi Asma Soofi Faezeh Almasi Shahnaz Hosseinzadeh Saeed Khalili Kamran Sheikhi Saeid Ferdousmakan Soroor Owrangi Minoovash Fahimi Hamidreza Zalpoor Mohsen Nabi Afjadi Zahra Payandeh Navid Pourzardosht |
| author_sort | Mohsen Karami Fath |
| collection | DOAJ |
| description | Abstract Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes in mechanisms of cell growth and proliferation. Epigenetics is the other factor with a crucial role in melanoma development. Epigenetic changes have become novel targets for treating patients suffering from melanoma. These changes can alter the expression of microRNAs and their interaction with target genes, which involves cell growth, differentiation, or even death. Given these circumstances, we conducted the present review to discuss the melanoma risk factors and represent the current knowledge about the factors related to its etiopathogenesis. Moreover, various epigenetic pathways, which are involved in melanoma progression, treatment, and chemo-resistance, as well as employed epigenetic factors as a solution to the problems, will be discussed in detail. |
| first_indexed | 2024-04-12T12:48:22Z |
| format | Article |
| id | doaj.art-90b9c0e0d05c4be9a40ab65b8f419d7f |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-12T12:48:22Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-90b9c0e0d05c4be9a40ab65b8f419d7f2022-12-22T03:32:32ZengBMCCancer Cell International1475-28672022-10-0122112310.1186/s12935-022-02738-0Current understanding of epigenetics role in melanoma treatment and resistanceMohsen Karami Fath0Ali Azargoonjahromi1Asma Soofi2Faezeh Almasi3Shahnaz Hosseinzadeh4Saeed Khalili5Kamran Sheikhi6Saeid Ferdousmakan7Soroor Owrangi8Minoovash Fahimi9Hamidreza Zalpoor10Mohsen Nabi Afjadi11Zahra Payandeh12Navid Pourzardosht13Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi UniversityShiraz University of Medical SciencesDepartment of Physical Chemistry, School of Chemistry, College of Sciences, University of TehranPharmaceutical Biotechnology Lab, Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of TehranDepartment of Microbiology, Parasitology and Immunology, Ardabil University of Medical SciencesDepartment of Biology Sciences, Shahid Rajaee Teacher Training UniversitySchool of Medicine, Kurdistan University of Medical SciencesDepartment of Pharmacy Practice, Nargund College of PharmacyStudent Research Committe, Fasa University of Medical SciencesFaculty of Medicine, Comenius UniversityShiraz Neuroscience Research Center, Shiraz University of Medical SciencesDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares UniversityDepartment Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska InstituteBiochemistry Department, Guilan University of Medical SciencesAbstract Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes in mechanisms of cell growth and proliferation. Epigenetics is the other factor with a crucial role in melanoma development. Epigenetic changes have become novel targets for treating patients suffering from melanoma. These changes can alter the expression of microRNAs and their interaction with target genes, which involves cell growth, differentiation, or even death. Given these circumstances, we conducted the present review to discuss the melanoma risk factors and represent the current knowledge about the factors related to its etiopathogenesis. Moreover, various epigenetic pathways, which are involved in melanoma progression, treatment, and chemo-resistance, as well as employed epigenetic factors as a solution to the problems, will be discussed in detail.https://doi.org/10.1186/s12935-022-02738-0MelanomaEpigeneticsDrug resistanceImmunotherapy |
| spellingShingle | Mohsen Karami Fath Ali Azargoonjahromi Asma Soofi Faezeh Almasi Shahnaz Hosseinzadeh Saeed Khalili Kamran Sheikhi Saeid Ferdousmakan Soroor Owrangi Minoovash Fahimi Hamidreza Zalpoor Mohsen Nabi Afjadi Zahra Payandeh Navid Pourzardosht Current understanding of epigenetics role in melanoma treatment and resistance Cancer Cell International Melanoma Epigenetics Drug resistance Immunotherapy |
| title | Current understanding of epigenetics role in melanoma treatment and resistance |
| title_full | Current understanding of epigenetics role in melanoma treatment and resistance |
| title_fullStr | Current understanding of epigenetics role in melanoma treatment and resistance |
| title_full_unstemmed | Current understanding of epigenetics role in melanoma treatment and resistance |
| title_short | Current understanding of epigenetics role in melanoma treatment and resistance |
| title_sort | current understanding of epigenetics role in melanoma treatment and resistance |
| topic | Melanoma Epigenetics Drug resistance Immunotherapy |
| url | https://doi.org/10.1186/s12935-022-02738-0 |
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