Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil
We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2002-10-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008&tlng=en |
| _version_ | 1828811689657630720 |
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| author | Ana Maria Barral de Martínez Edel Figueirêdo Barbosa Paulo César Pelegrino Ferreira Fabiola Adriene Cardoso Jussara Silveira Gabriela Sassi Cláudio Moss da Silva Vera Mendonça-Signorini Carlos Maurício de Figueiredo Antunes |
| author_facet | Ana Maria Barral de Martínez Edel Figueirêdo Barbosa Paulo César Pelegrino Ferreira Fabiola Adriene Cardoso Jussara Silveira Gabriela Sassi Cláudio Moss da Silva Vera Mendonça-Signorini Carlos Maurício de Figueiredo Antunes |
| author_sort | Ana Maria Barral de Martínez |
| collection | DOAJ |
| description | We conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%), C (22%) and F (3%). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices. |
| first_indexed | 2024-12-12T09:31:02Z |
| format | Article |
| id | doaj.art-90bade2fb6c04017ba5b6ed969ffbc54 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T09:31:02Z |
| publishDate | 2002-10-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-90bade2fb6c04017ba5b6ed969ffbc542022-12-22T00:28:51ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492002-10-01355471476Molecular epidemiology of HIV-1 in Rio Grande, RS, BrazilAna Maria Barral de Martínez0Edel Figueirêdo Barbosa1Paulo César Pelegrino Ferreira2Fabiola Adriene Cardoso3Jussara Silveira4Gabriela Sassi5Cláudio Moss da Silva6Vera Mendonça-Signorini7Carlos Maurício de Figueiredo Antunes8Fundação Universidade Federal do Rio GrandeUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisFundação Universidade Federal do Rio GrandeFundação Universidade Federal do Rio GrandeFundação Universidade Federal do Rio GrandeFundação Universidade Federal do Rio GrandeUniversidade Federal de Minas GeraisWe conducted a molecular epidemiological study to investigate HIV-1 strains in Rio Grande, southern Brazil, searching for an association with transmission mode and risk behavior. Patients (185) identified at an AIDS treatment reference Hospital, from 1994 to 1997, were included; from which 107 blood samples were obtained. Nested PCR was realized once for each sample; for amplified samples (69) HIV subtypes were classified using the heteroduplex mobility assay. Subtypes identified were B (75%), C (22%) and F (3%). All infections with C were diagnosed after 1994. Comparing patients with B and C, no differences were detected regarding demographic, clinical and laboratory characteristics; survival analysis did not reveal differences in HIV to AIDS evolution. A higher proportion of injecting drug users, IDU (not significant, p<.07) was found among those with C. This suggests that C may have been introduced in this area through IDU, and is being spread, probably by their sexual partners, to persons with other risk practices.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008&tlng=enMolecular epidemiologyHIV subtypesModes of transmission |
| spellingShingle | Ana Maria Barral de Martínez Edel Figueirêdo Barbosa Paulo César Pelegrino Ferreira Fabiola Adriene Cardoso Jussara Silveira Gabriela Sassi Cláudio Moss da Silva Vera Mendonça-Signorini Carlos Maurício de Figueiredo Antunes Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil Revista da Sociedade Brasileira de Medicina Tropical Molecular epidemiology HIV subtypes Modes of transmission |
| title | Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
| title_full | Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
| title_fullStr | Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
| title_full_unstemmed | Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
| title_short | Molecular epidemiology of HIV-1 in Rio Grande, RS, Brazil |
| title_sort | molecular epidemiology of hiv 1 in rio grande rs brazil |
| topic | Molecular epidemiology HIV subtypes Modes of transmission |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000500008&tlng=en |
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