Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand

Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand

In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties with a suitable ribofuranosephosphonate afforded the...

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Bibliographic Details
Main Authors: Lijun Song, Martijn D. P. Risseeuw, Izet Karalic, Matthew O. Barrett, Kyle A. Brown, T. Kendall Harden, Serge Van Calenbergh
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
nucleoside phosphonates
extended uridine
P2Y2 receptor
Online Access:http://www.mdpi.com/1420-3049/19/4/4313

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