Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle
H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X synthesis while cells with more poly(A)- isofor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20520-6 |
| _version_ | 1830192329137324032 |
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| author | Esther Griesbach Margarita Schlackow William F. Marzluff Nick J. Proudfoot |
| author_facet | Esther Griesbach Margarita Schlackow William F. Marzluff Nick J. Proudfoot |
| author_sort | Esther Griesbach |
| collection | DOAJ |
| description | H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X synthesis while cells with more poly(A)- isoform have sufficient H2A.X present in chromatin. |
| first_indexed | 2024-12-17T23:54:29Z |
| format | Article |
| id | doaj.art-90bcdc21996641338179013236fc44d3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T23:54:29Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-90bcdc21996641338179013236fc44d32022-12-21T21:28:06ZengNature PortfolioNature Communications2041-17232021-01-0112111410.1038/s41467-020-20520-6Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycleEsther Griesbach0Margarita Schlackow1William F. Marzluff2Nick J. Proudfoot3Sir William Dunn School of Pathology, University of Oxford, South Parks RoadSir William Dunn School of Pathology, University of Oxford, South Parks RoadDepartment of Biochemistry and Biophysics, University of North CarolinaSir William Dunn School of Pathology, University of Oxford, South Parks RoadH2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X synthesis while cells with more poly(A)- isoform have sufficient H2A.X present in chromatin.https://doi.org/10.1038/s41467-020-20520-6 |
| spellingShingle | Esther Griesbach Margarita Schlackow William F. Marzluff Nick J. Proudfoot Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle Nature Communications |
| title | Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle |
| title_full | Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle |
| title_fullStr | Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle |
| title_full_unstemmed | Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle |
| title_short | Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle |
| title_sort | dual rna 3 end processing of h2a x messenger rna maintains dna damage repair throughout the cell cycle |
| url | https://doi.org/10.1038/s41467-020-20520-6 |
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