Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness

Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness

Abstract The clinical translation of mesenchymal stem cells (MSCs) is limited by population heterogeneity and inconsistent responses to engineered signals. Specifically, the extent in which MSCs respond to mechanical cues varies significantly across MSC lines. Although induced pluripotent stem cells...

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Bibliographic Details
Main Authors: Kirstene A. Gultian, Roshni Gandhi, Khushi Sarin, Martina Sladkova-Faure, Matthew Zimmer, Giuseppe Maria de Peppo, Sebastián L. Vega
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12143-2

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