Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS<sub>2</sub> Protein Docks

Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS<sub>2</sub> Protein Docks

Integration-deficient lentiviral vectors (IDLVs) have recently generated increasing interest, not only as a tool for transient gene delivery, but also as a technique for detecting off-target cleavage in gene-editing methodologies which rely on customized endonucleases (ENs). Despite their broad pote...

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Bibliographic Details
Main Authors: Marina Cortijo-Gutiérrez, Sabina Sánchez-Hernández, María Tristán-Manzano, Noelia Maldonado-Pérez, Lourdes Lopez-Onieva, Pedro J. Real, Concha Herrera, Juan Antonio Marchal, Francisco Martin, Karim Benabdellah
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
IDLV
gene delivery
gene expression
gene editing
off-targets
Online Access:https://www.mdpi.com/1999-4923/13/8/1217

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