Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT)
Background: Non-alcoholic fatty liver disease (NAFLD) is a wide spectrum condition characterized by excessive liver fat accumulation in people who do not abuse alcohol. There is no effective medical treatment for NAFLD; therefore, most important recommendations to reduce liver steatosis are diet and...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/2072-6643/14/20/4310 |
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| author | Dominika Maciejewska-Markiewicz Arleta Drozd Joanna Palma Karina Ryterska Viktoria Hawryłkowicz Patrycja Załęska Ewa Wunsh Katarzyna Kozłowska-Petriczko Ewa Stachowska |
| author_facet | Dominika Maciejewska-Markiewicz Arleta Drozd Joanna Palma Karina Ryterska Viktoria Hawryłkowicz Patrycja Załęska Ewa Wunsh Katarzyna Kozłowska-Petriczko Ewa Stachowska |
| author_sort | Dominika Maciejewska-Markiewicz |
| collection | DOAJ |
| description | Background: Non-alcoholic fatty liver disease (NAFLD) is a wide spectrum condition characterized by excessive liver fat accumulation in people who do not abuse alcohol. There is no effective medical treatment for NAFLD; therefore, most important recommendations to reduce liver steatosis are diet and lifestyle, including proper physical activity. The aim of our study was to analyze the fatty acids and eicosanoids changes in the serum of patients who consumed high-fiber rolls for 8 weeks. Materials and Methods: The group of 28 Caucasian participants was randomly divided into two groups, those who received 24 g of fiber/day—from 2 buns of 12 g each (n = 14), and those who received 12 g of fiber/day—from 2 buns of 6 g (n = 14). At the beginning and on the last visit of the 8-week intervention, all patients underwent NAFLD evaluation, biochemical parameter measurements, and fatty acids and eicosanoids evaluation. Results: Patients who received 12 g of fiber had significantly reduced liver steatosis and body mass index. In the group who received 24 g of fiber/day, we observed a trend to liver steatosis reduction (<i>p</i> = 0.07) and significant decrease in aspartate aminotransferase (<i>p</i> = 0.03) and total cholesterol (<i>p</i> = 0.03). All changes in fatty acid and eicosanoids profile were similar. Fatty acids analysis revealed that extra fiber intake was associated with a significant increase in monounsaturated fatty acids and decrease in saturated fatty acids. Moreover, both groups showed increased concentration of gamma linoleic acid and docosahexaenoic acid. We also observed reduction in prostaglandin E<sub>2</sub>. Conclusions: Our study revealed that a high amount of fiber in the diet is associated with a reduction in fatty liver, although this effect was more pronounced in patients in the lower fiber group. However, regardless of the amount of fiber consumed, we observed significant changes in the profile of FAs, which may reflect the positive changes in the lipids liver metabolism. Regardless of the amount of fiber consumed, patients decreased the amount of PGE<sub>2</sub>, which may indicate the lack of disease progression associated with the development of inflammation. |
| first_indexed | 2024-03-09T19:39:36Z |
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| id | doaj.art-90c15bb61096493f809eff85e08d828b |
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| language | English |
| last_indexed | 2024-03-09T19:39:36Z |
| publishDate | 2022-10-01 |
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| series | Nutrients |
| spelling | doaj.art-90c15bb61096493f809eff85e08d828b2023-11-24T01:44:18ZengMDPI AGNutrients2072-66432022-10-011420431010.3390/nu14204310Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT)Dominika Maciejewska-Markiewicz0Arleta Drozd1Joanna Palma2Karina Ryterska3Viktoria Hawryłkowicz4Patrycja Załęska5Ewa Wunsh6Katarzyna Kozłowska-Petriczko7Ewa Stachowska8Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Biochemical Science, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandTranslational Medicine Group, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandTranslational Medicine Group, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandBackground: Non-alcoholic fatty liver disease (NAFLD) is a wide spectrum condition characterized by excessive liver fat accumulation in people who do not abuse alcohol. There is no effective medical treatment for NAFLD; therefore, most important recommendations to reduce liver steatosis are diet and lifestyle, including proper physical activity. The aim of our study was to analyze the fatty acids and eicosanoids changes in the serum of patients who consumed high-fiber rolls for 8 weeks. Materials and Methods: The group of 28 Caucasian participants was randomly divided into two groups, those who received 24 g of fiber/day—from 2 buns of 12 g each (n = 14), and those who received 12 g of fiber/day—from 2 buns of 6 g (n = 14). At the beginning and on the last visit of the 8-week intervention, all patients underwent NAFLD evaluation, biochemical parameter measurements, and fatty acids and eicosanoids evaluation. Results: Patients who received 12 g of fiber had significantly reduced liver steatosis and body mass index. In the group who received 24 g of fiber/day, we observed a trend to liver steatosis reduction (<i>p</i> = 0.07) and significant decrease in aspartate aminotransferase (<i>p</i> = 0.03) and total cholesterol (<i>p</i> = 0.03). All changes in fatty acid and eicosanoids profile were similar. Fatty acids analysis revealed that extra fiber intake was associated with a significant increase in monounsaturated fatty acids and decrease in saturated fatty acids. Moreover, both groups showed increased concentration of gamma linoleic acid and docosahexaenoic acid. We also observed reduction in prostaglandin E<sub>2</sub>. Conclusions: Our study revealed that a high amount of fiber in the diet is associated with a reduction in fatty liver, although this effect was more pronounced in patients in the lower fiber group. However, regardless of the amount of fiber consumed, we observed significant changes in the profile of FAs, which may reflect the positive changes in the lipids liver metabolism. Regardless of the amount of fiber consumed, patients decreased the amount of PGE<sub>2</sub>, which may indicate the lack of disease progression associated with the development of inflammation.https://www.mdpi.com/2072-6643/14/20/4310fiberfatty acidseicosanoidsNAFLDSCFA |
| spellingShingle | Dominika Maciejewska-Markiewicz Arleta Drozd Joanna Palma Karina Ryterska Viktoria Hawryłkowicz Patrycja Załęska Ewa Wunsh Katarzyna Kozłowska-Petriczko Ewa Stachowska Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT) Nutrients fiber fatty acids eicosanoids NAFLD SCFA |
| title | Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT) |
| title_full | Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT) |
| title_fullStr | Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT) |
| title_full_unstemmed | Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT) |
| title_short | Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients—Randomized Control Trials (RCT) |
| title_sort | fatty acids and eicosanoids change during high fiber diet in nafld patients randomized control trials rct |
| topic | fiber fatty acids eicosanoids NAFLD SCFA |
| url | https://www.mdpi.com/2072-6643/14/20/4310 |
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