Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis
(1) Infective endocarditis is a severe inflammatory disease associated with substantial mortality and morbidity. Alkaline phosphatase (AP) levels have been shown to change significantly during sepsis. Additionally, we previously found that a higher initial AP drop after cardiac surgery is associated...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/14/11728 |
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| author | Amila Kahrovic Thomas Poschner Anna Schober Philipp Angleitner Leila Alajbegovic Martin Andreas Doris Hutschala Ruud Brands Günther Laufer Dominik Wiedemann |
| author_facet | Amila Kahrovic Thomas Poschner Anna Schober Philipp Angleitner Leila Alajbegovic Martin Andreas Doris Hutschala Ruud Brands Günther Laufer Dominik Wiedemann |
| author_sort | Amila Kahrovic |
| collection | DOAJ |
| description | (1) Infective endocarditis is a severe inflammatory disease associated with substantial mortality and morbidity. Alkaline phosphatase (AP) levels have been shown to change significantly during sepsis. Additionally, we previously found that a higher initial AP drop after cardiac surgery is associated with unfavorable outcomes. Therefore, the course of AP after surgery for endocarditis is of special interest. (2) A total of 314 patients with active isolated left-sided infective endocarditis at the Department of Cardiac Surgery (Medical University of Vienna, Vienna, Austria) between 2009 and 2018 were enrolled in this retrospective analysis. Blood samples were analyzed at different time points (baseline, postoperative days 1–7, postoperative days 14 and 30). Patients were categorized according to relative alkaline phosphatase drop (≥30% vs. <30%). (3) A higher rate of postoperative renal replacement therapy with or without prior renal replacement therapy (7.4 vs. 21.8%; <i>p</i> = 0.001 and 6.7 vs. 15.6%; <i>p</i> = 0.015, respectively) and extracorporeal membrane oxygenation (2.2 vs. 19.0%; <i>p</i> = 0.000) was observed after a higher initial alkaline phosphatase drop. Short-term (30-day mortality 3.0 vs. 10.6%; <i>p</i> = 0.010) and long-term mortality (<i>p</i> = 0.008) were significantly impaired after a higher initial alkaline phosphatase drop. (4) The higher initial alkaline phosphatase drop was accompanied by impaired short- and long-term outcomes after cardiac surgery for endocarditis. Future risk assessment scores for cardiac surgery should consider alkaline phosphatase. |
| first_indexed | 2024-03-11T00:59:51Z |
| format | Article |
| id | doaj.art-90c2f59d4dac49ca8c6d49fdb3ce6234 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:59:51Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90c2f59d4dac49ca8c6d49fdb3ce62342023-11-18T19:44:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124141172810.3390/ijms241411728Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with EndocarditisAmila Kahrovic0Thomas Poschner1Anna Schober2Philipp Angleitner3Leila Alajbegovic4Martin Andreas5Doris Hutschala6Ruud Brands7Günther Laufer8Dominik Wiedemann9Department of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDivision of Cardiac Thoracic Vascular Anaesthesia and Intensive Care Medicine, Medical University of Vienna, 1090 Vienna, AustriaAlloksys Life Sciences BV, 6708 PW Wageningen, The NetherlandsDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, Austria(1) Infective endocarditis is a severe inflammatory disease associated with substantial mortality and morbidity. Alkaline phosphatase (AP) levels have been shown to change significantly during sepsis. Additionally, we previously found that a higher initial AP drop after cardiac surgery is associated with unfavorable outcomes. Therefore, the course of AP after surgery for endocarditis is of special interest. (2) A total of 314 patients with active isolated left-sided infective endocarditis at the Department of Cardiac Surgery (Medical University of Vienna, Vienna, Austria) between 2009 and 2018 were enrolled in this retrospective analysis. Blood samples were analyzed at different time points (baseline, postoperative days 1–7, postoperative days 14 and 30). Patients were categorized according to relative alkaline phosphatase drop (≥30% vs. <30%). (3) A higher rate of postoperative renal replacement therapy with or without prior renal replacement therapy (7.4 vs. 21.8%; <i>p</i> = 0.001 and 6.7 vs. 15.6%; <i>p</i> = 0.015, respectively) and extracorporeal membrane oxygenation (2.2 vs. 19.0%; <i>p</i> = 0.000) was observed after a higher initial alkaline phosphatase drop. Short-term (30-day mortality 3.0 vs. 10.6%; <i>p</i> = 0.010) and long-term mortality (<i>p</i> = 0.008) were significantly impaired after a higher initial alkaline phosphatase drop. (4) The higher initial alkaline phosphatase drop was accompanied by impaired short- and long-term outcomes after cardiac surgery for endocarditis. Future risk assessment scores for cardiac surgery should consider alkaline phosphatase.https://www.mdpi.com/1422-0067/24/14/11728alkaline phosphatasecardiac surgerycardio-pulmonary bypassendocarditiskidney |
| spellingShingle | Amila Kahrovic Thomas Poschner Anna Schober Philipp Angleitner Leila Alajbegovic Martin Andreas Doris Hutschala Ruud Brands Günther Laufer Dominik Wiedemann Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis International Journal of Molecular Sciences alkaline phosphatase cardiac surgery cardio-pulmonary bypass endocarditis kidney |
| title | Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis |
| title_full | Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis |
| title_fullStr | Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis |
| title_full_unstemmed | Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis |
| title_short | Increased Drop in Activity of Alkaline Phosphatase in Plasma from Patients with Endocarditis |
| title_sort | increased drop in activity of alkaline phosphatase in plasma from patients with endocarditis |
| topic | alkaline phosphatase cardiac surgery cardio-pulmonary bypass endocarditis kidney |
| url | https://www.mdpi.com/1422-0067/24/14/11728 |
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