Comparative analysis of the scanner rSPECT sensitivity: using GAMOS: a newGeant4-based framework
The molecular imaging of in vivo cellular processes using preclinical animal studies and SPECT technique is one of the main reasons for the design of new devices with high spatial resolution. As an auxiliary tool, Monte Carlo simulation has allowed the effective characterization and optimization of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centro de Gestión de la Información y Desarrollo de la Energía (CUBAENERGIA)
2012-01-01
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| Series: | Nucleus |
| Subjects: | |
| Online Access: | http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/559 |
| Summary: | The molecular imaging of in vivo cellular processes using preclinical animal studies and SPECT technique is one of the main reasons for the design of new devices with high spatial resolution. As an auxiliary tool, Monte Carlo simulation has allowed the effective characterization and optimization of those medical imaging systems. At present there is a new simulation framework called GAMOS (GEANT4-based Architecture for Medicine-Oriented Simulations); which code, libraries and particle transport method correspond to those developed by GEANT4 and contains specific applications for nuclear medicine. This tool has been already validated for PET technique by comparison with experimental data, while not yet been done the correct evaluation of GAMOS for SPECT systems. Present work have demonstrated the potential of GAMOS in obtaining simulated realistic data using this nuclear imaging technique. For this purpose, simulation of a novel installation "rSPECT", devote to study rodents, has been done. The study comprises the collimation and detection geometries and the fundamental characteristics of the previuos published experimental measurements for rSPECT installation. Studies have been done using and 20% energy window. Sensitivity values obtained by simulation revealed an acceptable agreement with experimental values. Therefore we can conclude that simulation results have shown good agreement with the real data. This fact allowed us to estimate the behavior of the new GEANT4 simulation platform "GAMOS" in SPECT applications and have demonstrated the feasibility of reproducing experimental data. |
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| ISSN: | 0864-084X 2075-5635 |