Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study
In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospital...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600003&lng=en&tlng=en |
| _version_ | 1818139721374629888 |
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| author | Ana Cristina Gales Heber D Azevedo Rosângela Ferraz Cereda Raquel Girardello Danilo Elias Xavier |
| author_facet | Ana Cristina Gales Heber D Azevedo Rosângela Ferraz Cereda Raquel Girardello Danilo Elias Xavier |
| author_sort | Ana Cristina Gales |
| collection | DOAJ |
| description | In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospitalized at 18 medical centers between May/08 and March/09. Each hospital was asked to submit 50 single Gram-negative bacilli isolated from blood, lower respiratory tract or intraabdominal secretions. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using Clinical Laboratory Standards Institute (CLSI) microdilution method at a central laboratory. CLSI M100-S21 (2011) or US-FDA package insert criteria (tigecycline) was used for interpretation of the antimicrobial susceptibility results. Doripenem was as active as meropenem and more active than imipenem against E. coli and K. pneumoniae isolates. A total of 50.0% of Enterobacter spp. isolates were resistant to ceftazidime but 85.7% of them were inhibited at doripenem MICs < 1 µg/mL. Polymyxin B was the only agent to show potent activity against Acinetobacter spp. (MIC50/90, < 0.5/1 µg/mL) and P. aeruginosa (MIC50/90, 1/2 µg/mL). Although high rates of imipenem (53.1%) and meropenem (44.5%) resistance were detected among P. aeruginosa, doripenem showed MIC50 of 16 µg/mL against imipenem-resistant P. aeruginosa and inhibited a greater number of imipenem-resistant P. aeruginosa (10.5%) at MIC values of < 4 µg/mL than did meropenem (0.0%). In this study, doripenem showed similar in vitro activity to that of meropenem and retained some activity against imipenem-resistant P. aeruginosa isolated from Brazilian medical centers. |
| first_indexed | 2024-12-11T10:32:35Z |
| format | Article |
| id | doaj.art-90c5d3b0bbcb44388233f62baa195637 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-11T10:32:35Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-90c5d3b0bbcb44388233f62baa1956372022-12-22T01:10:51ZengElsevierBrazilian Journal of Infectious Diseases1678-439115651352010.1590/S1413-86702011000600003S1413-86702011000600003Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian studyAna Cristina Gales0Heber D Azevedo1Rosângela Ferraz Cereda2Raquel Girardello3Danilo Elias Xavier4Universidade Federal de São PauloJanssen-CilagJanssen-CilagUniversidade Federal de São PauloUniversidade Federal de São PauloIn vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospitalized at 18 medical centers between May/08 and March/09. Each hospital was asked to submit 50 single Gram-negative bacilli isolated from blood, lower respiratory tract or intraabdominal secretions. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using Clinical Laboratory Standards Institute (CLSI) microdilution method at a central laboratory. CLSI M100-S21 (2011) or US-FDA package insert criteria (tigecycline) was used for interpretation of the antimicrobial susceptibility results. Doripenem was as active as meropenem and more active than imipenem against E. coli and K. pneumoniae isolates. A total of 50.0% of Enterobacter spp. isolates were resistant to ceftazidime but 85.7% of them were inhibited at doripenem MICs < 1 µg/mL. Polymyxin B was the only agent to show potent activity against Acinetobacter spp. (MIC50/90, < 0.5/1 µg/mL) and P. aeruginosa (MIC50/90, 1/2 µg/mL). Although high rates of imipenem (53.1%) and meropenem (44.5%) resistance were detected among P. aeruginosa, doripenem showed MIC50 of 16 µg/mL against imipenem-resistant P. aeruginosa and inhibited a greater number of imipenem-resistant P. aeruginosa (10.5%) at MIC values of < 4 µg/mL than did meropenem (0.0%). In this study, doripenem showed similar in vitro activity to that of meropenem and retained some activity against imipenem-resistant P. aeruginosa isolated from Brazilian medical centers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600003&lng=en&tlng=encarbapenemsGram-negative bacteriaBrazil |
| spellingShingle | Ana Cristina Gales Heber D Azevedo Rosângela Ferraz Cereda Raquel Girardello Danilo Elias Xavier Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study Brazilian Journal of Infectious Diseases carbapenems Gram-negative bacteria Brazil |
| title | Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study |
| title_full | Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study |
| title_fullStr | Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study |
| title_full_unstemmed | Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study |
| title_short | Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study |
| title_sort | antimicrobial activity of doripenem against gram negative pathogens results from invita a dori brazilian study |
| topic | carbapenems Gram-negative bacteria Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600003&lng=en&tlng=en |
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