A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report
Giant cell tumors of bone (GCTB) are commonly benign neoplasms and characterized by regional progressive and destructive lesions. They have a malignant potential and the capacity to metastasis. Incidents of GCTB are reported in 20% of all benign and 5% of all malignant bone tumors and pediatric case...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-09-01
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| Series: | Journal of Pediatric Research |
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http://jpedres.org/archives/archive-detail/article-preview/a-newborn-with-giant-cell-tumor-of-the-occipital-b/30522
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| author | Ersin Töret Bengü Demirağ Şebnem Çalakvur Başak Doğanavşargil Tuncer Turhan |
| author_facet | Ersin Töret Bengü Demirağ Şebnem Çalakvur Başak Doğanavşargil Tuncer Turhan |
| author_sort | Ersin Töret |
| collection | DOAJ |
| description | Giant cell tumors of bone (GCTB) are commonly benign neoplasms and characterized by regional progressive and destructive lesions. They have a malignant potential and the capacity to metastasis. Incidents of GCTB are reported in 20% of all benign and 5% of all malignant bone tumors and pediatric cases account for less than 5% of all them. The first line treatment strategy for GCTBs is surgical resection. A male baby presented at our hospital on his 10th day of life suffering from respiratory distress and persistent vomiting. His blood and urine panels were within normal parameters. CMRI was performed to evaluate his condition. The CMRI report noted a “suspected 4x3 cm contrasted bone-derived malignant-looking mass at the left posterior fossa of the cranium”. The biopsy confirmed: “A grade 1-2 giant cell tumor of bone”. Surgical resection was not possible because of the location of the mass and its proximity to blood vessels but chemotherapy was the one strategy available in this particular case. The chemotherapy regimen consisted of cisplatin 1 mg/kg/day (1-3 days) and doxorubicin 1 mg/kg/day (1,2 days) and was applied four times every month. Using CMRI, we noted a reduction in mass of more than 50% after two sessions and complete regression after four sessions. The patient was given regular follow-ups with no evidence of recurrence and co-morbidity were observed over the next 60 months. We recommend chemotherapy as a successful alternative strategy when surgical resection, radiotherapy, and other therapies are not applicable for GCTBs. |
| first_indexed | 2024-04-10T12:20:17Z |
| format | Article |
| id | doaj.art-90c67530f0cc4315856e9bc53dc71e0d |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T12:20:17Z |
| publishDate | 2019-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-90c67530f0cc4315856e9bc53dc71e0d2023-02-15T16:15:29ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782019-09-016325625810.4274/jpr.galenos.2019.0590013049054A Newborn with Giant Cell Tumor of the Occipital Bone: Case ReportErsin Töret0Bengü Demirağ1Şebnem Çalakvur2Başak Doğanavşargil3Tuncer Turhan4 University of Health Sciences, Dr. Behçet Uz Children’s Training and Research, Clinic of Pediatric Hematology Oncology, İzmir, Turkey University of Health Sciences, Dr. Behçet Uz Children’s Training and Research, Clinic of Pediatric Hematology Oncology, İzmir, Turkey University of Health Sciences, Dr. Behçet Uz Children’s Training and Research, Clinic of Neonatology, İzmir, Turkey Ege University Faculty of Medicine, Department of Pathology, İzmir, Turkey Ege University Faculty of Medicine, Department of Neurosurgery, İzmir, Turkey Giant cell tumors of bone (GCTB) are commonly benign neoplasms and characterized by regional progressive and destructive lesions. They have a malignant potential and the capacity to metastasis. Incidents of GCTB are reported in 20% of all benign and 5% of all malignant bone tumors and pediatric cases account for less than 5% of all them. The first line treatment strategy for GCTBs is surgical resection. A male baby presented at our hospital on his 10th day of life suffering from respiratory distress and persistent vomiting. His blood and urine panels were within normal parameters. CMRI was performed to evaluate his condition. The CMRI report noted a “suspected 4x3 cm contrasted bone-derived malignant-looking mass at the left posterior fossa of the cranium”. The biopsy confirmed: “A grade 1-2 giant cell tumor of bone”. Surgical resection was not possible because of the location of the mass and its proximity to blood vessels but chemotherapy was the one strategy available in this particular case. The chemotherapy regimen consisted of cisplatin 1 mg/kg/day (1-3 days) and doxorubicin 1 mg/kg/day (1,2 days) and was applied four times every month. Using CMRI, we noted a reduction in mass of more than 50% after two sessions and complete regression after four sessions. The patient was given regular follow-ups with no evidence of recurrence and co-morbidity were observed over the next 60 months. We recommend chemotherapy as a successful alternative strategy when surgical resection, radiotherapy, and other therapies are not applicable for GCTBs. http://jpedres.org/archives/archive-detail/article-preview/a-newborn-with-giant-cell-tumor-of-the-occipital-b/30522 Giant cell tumor of bonenewbornchemotherapy |
| spellingShingle | Ersin Töret Bengü Demirağ Şebnem Çalakvur Başak Doğanavşargil Tuncer Turhan A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report Journal of Pediatric Research Giant cell tumor of bone newborn chemotherapy |
| title | A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report |
| title_full | A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report |
| title_fullStr | A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report |
| title_full_unstemmed | A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report |
| title_short | A Newborn with Giant Cell Tumor of the Occipital Bone: Case Report |
| title_sort | newborn with giant cell tumor of the occipital bone case report |
| topic | Giant cell tumor of bone newborn chemotherapy |
| url |
http://jpedres.org/archives/archive-detail/article-preview/a-newborn-with-giant-cell-tumor-of-the-occipital-b/30522
|
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