Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression
Emerging evidence suggests a link between atopic dermatitis (AD) and gastrointestinal disorders, particularly in relation to gut microbial dysbiosis. This study explored the potential exacerbation of AD by gut inflammation and microbial imbalances using an irritable bowel syndrome (IBS) mouse model....
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/2753 |
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| author | Jae-Hwan Jang Sun-Young Jang Sora Ahn Ju-Young Oh Mijung Yeom Seok-Jae Ko Jae-Woo Park Soon-Kyeong Kwon Kyuseok Kim In-Seon Lee Dae-Hyun Hahm Hi-Joon Park |
| author_facet | Jae-Hwan Jang Sun-Young Jang Sora Ahn Ju-Young Oh Mijung Yeom Seok-Jae Ko Jae-Woo Park Soon-Kyeong Kwon Kyuseok Kim In-Seon Lee Dae-Hyun Hahm Hi-Joon Park |
| author_sort | Jae-Hwan Jang |
| collection | DOAJ |
| description | Emerging evidence suggests a link between atopic dermatitis (AD) and gastrointestinal disorders, particularly in relation to gut microbial dysbiosis. This study explored the potential exacerbation of AD by gut inflammation and microbial imbalances using an irritable bowel syndrome (IBS) mouse model. Chronic gut inflammation was induced in the model by intrarectal injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS), followed by a 4-week development period. We noted significant upregulation of proinflammatory cytokines in the colon and evident gut microbial dysbiosis in the IBS mice. Additionally, these mice exhibited impaired gut barrier function, increased permeability, and elevated systemic inflammation markers such as IL-6 and LPS. A subsequent MC903 challenge on the right cheek lasting for 7 days revealed more severe AD symptoms in IBS mice compared to controls. Further, fecal microbial transplantation (FMT) from IBS mice resulted in aggravated AD symptoms, a result similarly observed with FMT from an IBS patient. Notably, an increased abundance of <i>Alistipes</i> in the feces of IBS mice correlated with heightened systemic and localized inflammation in both the gut and skin. These findings collectively indicate that chronic gut inflammation and microbial dysbiosis in IBS are critical factors exacerbating AD, highlighting the integral relationship between gut and skin health. |
| first_indexed | 2024-04-25T00:29:09Z |
| format | Article |
| id | doaj.art-90c75af4c2144ea1b8f3182d81b34417 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:29:09Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90c75af4c2144ea1b8f3182d81b344172024-03-12T16:46:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255275310.3390/ijms25052753Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis ProgressionJae-Hwan Jang0Sun-Young Jang1Sora Ahn2Ju-Young Oh3Mijung Yeom4Seok-Jae Ko5Jae-Woo Park6Soon-Kyeong Kwon7Kyuseok Kim8In-Seon Lee9Dae-Hyun Hahm10Hi-Joon Park11Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 05854, Republic of KoreaDepartment of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Anatomy and Information Sciences, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Anatomy and Information Sciences, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaAcupuncture & Meridian Science Research Center, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDivision of Applied Life Science (BK21), Gyeongsang National University, Jinju 52828, Republic of KoreaDepartment of Ophthalmology, Otorhinolaryngology, and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaAcupuncture & Meridian Science Research Center, Kyung Hee University, Seoul 02447, Republic of KoreaAcupuncture & Meridian Science Research Center, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Anatomy and Information Sciences, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaEmerging evidence suggests a link between atopic dermatitis (AD) and gastrointestinal disorders, particularly in relation to gut microbial dysbiosis. This study explored the potential exacerbation of AD by gut inflammation and microbial imbalances using an irritable bowel syndrome (IBS) mouse model. Chronic gut inflammation was induced in the model by intrarectal injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS), followed by a 4-week development period. We noted significant upregulation of proinflammatory cytokines in the colon and evident gut microbial dysbiosis in the IBS mice. Additionally, these mice exhibited impaired gut barrier function, increased permeability, and elevated systemic inflammation markers such as IL-6 and LPS. A subsequent MC903 challenge on the right cheek lasting for 7 days revealed more severe AD symptoms in IBS mice compared to controls. Further, fecal microbial transplantation (FMT) from IBS mice resulted in aggravated AD symptoms, a result similarly observed with FMT from an IBS patient. Notably, an increased abundance of <i>Alistipes</i> in the feces of IBS mice correlated with heightened systemic and localized inflammation in both the gut and skin. These findings collectively indicate that chronic gut inflammation and microbial dysbiosis in IBS are critical factors exacerbating AD, highlighting the integral relationship between gut and skin health.https://www.mdpi.com/1422-0067/25/5/2753atopic dermatitisgut microbial dysbiosissystemic inflammationirritable bowel syndrome |
| spellingShingle | Jae-Hwan Jang Sun-Young Jang Sora Ahn Ju-Young Oh Mijung Yeom Seok-Jae Ko Jae-Woo Park Soon-Kyeong Kwon Kyuseok Kim In-Seon Lee Dae-Hyun Hahm Hi-Joon Park Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression International Journal of Molecular Sciences atopic dermatitis gut microbial dysbiosis systemic inflammation irritable bowel syndrome |
| title | Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression |
| title_full | Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression |
| title_fullStr | Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression |
| title_full_unstemmed | Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression |
| title_short | Chronic Gut Inflammation and Dysbiosis in IBS: Unraveling Their Contribution to Atopic Dermatitis Progression |
| title_sort | chronic gut inflammation and dysbiosis in ibs unraveling their contribution to atopic dermatitis progression |
| topic | atopic dermatitis gut microbial dysbiosis systemic inflammation irritable bowel syndrome |
| url | https://www.mdpi.com/1422-0067/25/5/2753 |
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