Ubiquitin Ligases in Longevity and Aging Skeletal Muscle
The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome system (UPS) and lysosome–autophagy system leading to impaired function an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7602 |
| _version_ | 1797433544719466496 |
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| author | David C. Hughes Leslie M. Baehr David S. Waddell Adam P. Sharples Sue C. Bodine |
| author_facet | David C. Hughes Leslie M. Baehr David S. Waddell Adam P. Sharples Sue C. Bodine |
| author_sort | David C. Hughes |
| collection | DOAJ |
| description | The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome system (UPS) and lysosome–autophagy system leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In the instance of skeletal muscle, the impairment of function occurs early in the aging process and is dependent on proteostatic mechanisms. The UPS plays a pivotal role in degradation of misfolded and aggregated proteins. For the purpose of this review, we will discuss the role of the UPS system in the context of age-related loss of muscle mass and function. We highlight the significant role that E3 ubiquitin ligases play in the turnover of key components (e.g., mitochondria and neuromuscular junction) essential to skeletal muscle function and the influence of aging. In addition, we will briefly discuss the contribution of the UPS system to lifespan. By understanding the UPS system as part of the proteostasis network in age-related diseases and disorders such as sarcopenia, new discoveries can be made and new interventions can be developed which will preserve muscle function and maintain quality of life with advancing age. |
| first_indexed | 2024-03-09T10:18:29Z |
| format | Article |
| id | doaj.art-90c762f4d9004d4da5656378f294d9b7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:18:29Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90c762f4d9004d4da5656378f294d9b72023-12-01T22:14:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314760210.3390/ijms23147602Ubiquitin Ligases in Longevity and Aging Skeletal MuscleDavid C. Hughes0Leslie M. Baehr1David S. Waddell2Adam P. Sharples3Sue C. Bodine4Division of Endocrinology and Metabolism, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USADivision of Endocrinology and Metabolism, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USADepartment of Biology, University of North Florida, Jacksonville, FL 32224, USAInstitute for Physical Performance, Norwegian School of Sport Sciences (NiH), 0863 Oslo, NorwayDivision of Endocrinology and Metabolism, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAThe development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome system (UPS) and lysosome–autophagy system leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In the instance of skeletal muscle, the impairment of function occurs early in the aging process and is dependent on proteostatic mechanisms. The UPS plays a pivotal role in degradation of misfolded and aggregated proteins. For the purpose of this review, we will discuss the role of the UPS system in the context of age-related loss of muscle mass and function. We highlight the significant role that E3 ubiquitin ligases play in the turnover of key components (e.g., mitochondria and neuromuscular junction) essential to skeletal muscle function and the influence of aging. In addition, we will briefly discuss the contribution of the UPS system to lifespan. By understanding the UPS system as part of the proteostasis network in age-related diseases and disorders such as sarcopenia, new discoveries can be made and new interventions can be developed which will preserve muscle function and maintain quality of life with advancing age.https://www.mdpi.com/1422-0067/23/14/7602protein degradationproteostasisE3 ubiquitin ligasehealthspansarcopenia |
| spellingShingle | David C. Hughes Leslie M. Baehr David S. Waddell Adam P. Sharples Sue C. Bodine Ubiquitin Ligases in Longevity and Aging Skeletal Muscle International Journal of Molecular Sciences protein degradation proteostasis E3 ubiquitin ligase healthspan sarcopenia |
| title | Ubiquitin Ligases in Longevity and Aging Skeletal Muscle |
| title_full | Ubiquitin Ligases in Longevity and Aging Skeletal Muscle |
| title_fullStr | Ubiquitin Ligases in Longevity and Aging Skeletal Muscle |
| title_full_unstemmed | Ubiquitin Ligases in Longevity and Aging Skeletal Muscle |
| title_short | Ubiquitin Ligases in Longevity and Aging Skeletal Muscle |
| title_sort | ubiquitin ligases in longevity and aging skeletal muscle |
| topic | protein degradation proteostasis E3 ubiquitin ligase healthspan sarcopenia |
| url | https://www.mdpi.com/1422-0067/23/14/7602 |
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