Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan
<p>Abstract</p> <p>Background</p> <p>Diabetes mellitus (DM) has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan’s insurance data.</p> <p>Methods</p> <p>We identified 549 pat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-230X/12/177 |
| _version_ | 1818542538867343360 |
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| author | Cheng Kao-Chi Chen Yu-Lung Lai Shih-Wei Tsai Pang-Yao Sung Fung-Chang |
| author_facet | Cheng Kao-Chi Chen Yu-Lung Lai Shih-Wei Tsai Pang-Yao Sung Fung-Chang |
| author_sort | Cheng Kao-Chi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Diabetes mellitus (DM) has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan’s insurance data.</p> <p>Methods</p> <p>We identified 549 patients with esophageal cancer newly diagnosed in 2000-2009 and randomly selected 2196 controls without any cancer, frequency matched by sex, age and diagnosis year of cases. Logistic regression model estimated odds ratios (ORs) and 95% confidence intervals (CI) of esophageal cancer associated with DM, sex, age. co-morbidities and medications.</p> <p>Results</p> <p>Cases were more prevalent than controls for alcoholism and esophageal disorders and using nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors but not DM. Esophageal cancer had no association with DM (OR 0.99, 95% CI 0.71-1.37), but significantly associated with alcoholism (OR 14.1, 95% CI 7.87-25.4), esophageal ulcer (OR 10.1, 95% CI 5.70-17.9), esophageal reflux (OR 3.47, 95% CI 2.14-5.26) and uses of NSAIDs (OR 2.73, 95% CI 1.80-4.13). An elevated risk of esophageal cancer appeared in DM patients taking insulin (OR 2.57, 95% CI 1.08-6.15) or sulfonyurea (OR 3.80, 95% CI 1.16-12.5).</p> <p>Conclusions</p> <p>Patients with DM are not at higher risk for esophagus cancer. However, esophageal disorders and anti-diabetic drugs are associated with the risk of the disease.</p> |
| first_indexed | 2024-12-11T22:23:24Z |
| format | Article |
| id | doaj.art-90c876dbec7145a58429d798a33f4228 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-11T22:23:24Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-90c876dbec7145a58429d798a33f42282022-12-22T00:48:22ZengBMCBMC Gastroenterology1471-230X2012-12-0112117710.1186/1471-230X-12-177Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in TaiwanCheng Kao-ChiChen Yu-LungLai Shih-WeiTsai Pang-YaoSung Fung-Chang<p>Abstract</p> <p>Background</p> <p>Diabetes mellitus (DM) has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan’s insurance data.</p> <p>Methods</p> <p>We identified 549 patients with esophageal cancer newly diagnosed in 2000-2009 and randomly selected 2196 controls without any cancer, frequency matched by sex, age and diagnosis year of cases. Logistic regression model estimated odds ratios (ORs) and 95% confidence intervals (CI) of esophageal cancer associated with DM, sex, age. co-morbidities and medications.</p> <p>Results</p> <p>Cases were more prevalent than controls for alcoholism and esophageal disorders and using nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors but not DM. Esophageal cancer had no association with DM (OR 0.99, 95% CI 0.71-1.37), but significantly associated with alcoholism (OR 14.1, 95% CI 7.87-25.4), esophageal ulcer (OR 10.1, 95% CI 5.70-17.9), esophageal reflux (OR 3.47, 95% CI 2.14-5.26) and uses of NSAIDs (OR 2.73, 95% CI 1.80-4.13). An elevated risk of esophageal cancer appeared in DM patients taking insulin (OR 2.57, 95% CI 1.08-6.15) or sulfonyurea (OR 3.80, 95% CI 1.16-12.5).</p> <p>Conclusions</p> <p>Patients with DM are not at higher risk for esophagus cancer. However, esophageal disorders and anti-diabetic drugs are associated with the risk of the disease.</p>http://www.biomedcentral.com/1471-230X/12/177Case-control studyDiabetesEsophagus cancerInsulin |
| spellingShingle | Cheng Kao-Chi Chen Yu-Lung Lai Shih-Wei Tsai Pang-Yao Sung Fung-Chang Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan BMC Gastroenterology Case-control study Diabetes Esophagus cancer Insulin |
| title | Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan |
| title_full | Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan |
| title_fullStr | Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan |
| title_full_unstemmed | Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan |
| title_short | Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in Taiwan |
| title_sort | risk of esophagus cancer in diabetes mellitus a population based case control study in taiwan |
| topic | Case-control study Diabetes Esophagus cancer Insulin |
| url | http://www.biomedcentral.com/1471-230X/12/177 |
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